Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives

被引：7

作者：

Bogh, Helena Lykke ^{[1
,2
]}

Stanislaus, Sharleny ^{[1
]}

Kjaerstad, Hanne Lie ^{[1
]}

Sletved, Kimie Stefanie Ormstrup ^{[1
,2
]}

Forman, Julie Lyng ^{[3
]}

Poulsen, Henrik Enghusen ^{[2
,4
,5
,6
]}

Vinberg, Maj ^{[1
,2
,7
]}

Kessing, Lars Vedel ^{[1
,2
]}

Coello, Klara ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Rigshosp, Copenhagen, Denmark

[2] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[3] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark

[4] Copenhagen Univ Hosp Bispebjerg Frederiksberg, Dept Endocrinol, Frederiksberg, Denmark

[5] Copenhagen Univ Hosp North Zealand, Dept Cardiol, Hillerod, Denmark

[6] North Zealand Hosp Hillerd, Res Unit, Hillerod, Denmark

[7] Copenhagen Univ Hosp, Psychiat Ctr North Zealand, Psychiat Res Unit, Hillerod, Denmark

来源：

TRANSLATIONAL PSYCHIATRY | 2022年 / 12卷 / 01期

关键词：

SUBCLINICAL ATHEROSCLEROSIS; STRESS MARKERS; GENERATED DNA; RATING-SCALE; RNA DAMAGE; DISEASE; PREVALENCE; 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; METAANALYSIS; RELIABILITY;

D O I：

10.1038/s41398-022-02095-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.

引用

页数：10

共 42 条

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