Advances in the synthesis and application of self-assembling biomaterials

被引:6
作者
Bhorkar, Isha [1 ,3 ]
Dhoble, Abhishek S. [2 ]
机构
[1] Birla Inst Technol & Sci BITS, Dept Chem Engn, Pilani, Rajasthan, India
[2] Indian Inst Technol BHU, Sch Biochem Engn, Varanasi 221005, Uttar Pradesh, India
[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
关键词
Biomaterials; Self; -organization; Biomimicry; Drug delivery; Tissue regeneration; SOLID LIPID NANOPARTICLES; PEPTIDE AMPHIPHILES; MIMETIC PEPTIDE; TRIPLE-HELIX; IN-VITRO; DNA; HYDROGELS; FILMS; NANOFIBERS; MONOLAYERS;
D O I
10.1016/j.pbiomolbio.2021.07.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present study scrutinized some of the crucial advancements in the synthesis and functionalisation of self-assembling biomaterials for application in biomedicine. The basic concept of self-organization was discussed along with the mechanisms and methods involved in its implementation with biomaterials. Further, several recent applications of this technology in the biological and medical domain, and the avenues for future research and development were presented. This study brought to focus the vast potential of basic and applied research involved, especially in the context of hybrids and composites, as well as the difference in pace of new developments for different types of biomolecular materials. As nanobiotechnology matures, the tools and techniques available for developing and controlling selfassembled biomaterials as well as studying their interaction with biological tissue, will grow exponentially. Presently, self-assembly remains a potent tool for the synthesis of functional biomaterials. (c) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页码:46 / 62
页数:17
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