Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering

被引：15

作者：

Rashid, Saqib ^{[1
]}

Vita, Gian Marco ^{[2
]}

Persichetti, Luca ^{[2
]}

Iucci, Giovanna ^{[2
]}

Battocchio, Chiara ^{[2
]}

Daniel, Rostislav ^{[3
]}

Visaggio, Daniela ^{[2
]}

Marsotto, Martina ^{[2
]}

Visca, Paolo ^{[2
]}

Bemporad, Edoardo ^{[1
]}

Ascenzi, Paolo ^{[2
,4
]}

Capellini, Giovanni ^{[2
]}

Sebastiani, Marco ^{[1
]}

di Masi, Alessandra ^{[2
]}

机构：

[1] Univ Roma Tre, Dept Engn, Via Vasca Navale 79, I-00146 Rome, Italy

[2] Univ Roma Tre, Dept Sci, Viale Guglielmo Marconi 446, I-00146 Rome, Italy

[3] Univ Leoben, Dept Mat Sci, Franz Josef Str 18, A-8700 Leoben, Austria

[4] Accademia Nazl Lincei, Via Lungara 10, I-00165 Rome, Italy

来源：

APPLIED SURFACE SCIENCE | 2022年 / 573卷

关键词：

Bactericidal; Biocompatibility; Copper; Human fibroblast; physical vapor deposition (PVD); Silver; Titanium; Thin films; HUMAN GINGIVAL FIBROBLASTS; REGENERATIVE MEDICINE; ELASTIC-MODULUS; SILVER ION; SURFACES; ALLOY; CYTOTOXICITY; INDENTATION; ATTACHMENT; RESISTANT;

D O I：

10.1016/j.apsusc.2021.151604

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Mechanical robustness, biocompatibility, and antibacterial performance are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering (MSPVD) on Si substrates. Thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloys display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.

引用

页数：12

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