Titanium 3,3′-modified-biphenolate complexes atropisomerically controlled by TADDOLs:: Novel chiral Lewis acid catalysts for asymmetric methylation with an achiral methyl-titanium reagent

被引：0

作者：

Ueki, M ^{[1
]}

Matsumoto, Y ^{[1
]}

Jodry, JJ ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

来源：

SYNLETT | 2001年 / 12期

关键词：

asymmetric methylation; atropisomer; chiral Lewis acid catalyst; chiral titanium complex; 3,3 '-modified biphenols;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral Ti complexes, which are constituted of 3,3'-modified-biphenolate (BIPOLate) ligands atropisomerically controlled by (R)-TADDOLs, are shown to be novel chiral Lewis acid catalysts for the methylation reaction of aldehydes with an achiral methyl-titanium reagent, Thus, the chiral 3,3'-modified BIPOLate/TADDOLate-Ti complexes give enhanced enantioselectivities up to 100% enantiomeric excess.

引用

页码：1889 / 1892

页数：4