Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease

被引：30

作者：

Koeyers, Wendy Jane ^{[1
]}

Van der Geer, Simone ^{[1
]}

Krekels, Gertruud ^{[1
]}

机构：

[1] Catharina Hosp, NL-5602 ZA Eindhoven, Netherlands

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2008年 / 19卷 / 04期

关键词：

benign familial pemphigus; botulinum toxin type A; BTXA; Hailey-Hailey disease; HH-disease;

D O I：

10.1080/09546630801955135

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed. Objective: To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease. Methods: The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport (R) was started in all six cases. Results: Marked improvement of the lesions was achieved with few side effects in all patients. Conclusion: Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.

引用

页码：251 / 254

页数：4

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