Prevalence of antibodies against Hepatitis D virus (HDV) in blood donors in Northern Germany

被引：4

作者：

Juhl, David ^{[1
]}

Chudy, Michael ^{[2
]}

Goerg, Siegfried ^{[1
]}

Hennig, Holger ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Inst Transfus Med, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[2] Paul Ehrlich Inst, Fed Inst Vaccines & Biomed, Langen, Germany

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2020年 / 59卷 / 03期

关键词：

Hepatitis D virus; HDV; Anti-HDV; Blood donors; DELTA; INFECTION; FEATURES;

D O I：

10.1016/j.transci.2020.102721

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To assess the prevalence of HDV infections in German blood donors. Method: 167 donors with acute/chronic or resolved HBV infection and detectable antibodies against Hepatitis B core antigen (anti-HBc) were tested for antibodies against HDV (anti-HDV) by competitive ELISA. Samples with detectable anti-HDV or with HBsAg and/or HBV DNA were additionally investigated for HDV RNA. Results: In nine (5.4 %) of the 167 donors, also HBsAg and HBV DNA were detectable. Anti-HDV was detectable in two of the 167 donors (1.2 %), additional four donors (2.4 %) had a borderline result. All of these donors tested negative for HBsAg and HBV DNA. Neither in samples with anti-HDV nor in HBsAg-/HBV DNA-positive samples, HDV RNA was detectable. Conclusions: At least 1.2 % of anti-HBc-positive blood donors have had an HDV infection. Although there is some evidence for a somewhat higher prevalence of HDV, the overall prevalence of HDV in Northern Germany is low.

引用

页数：4

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