Collagen-induced arthritis and related animal models: How much of their pathogenesis is auto-immune, how much is auto-inflammatory?

被引：49
作者：
Billiau, Alfons [1 ]
Matthys, Patrick [1 ]
机构：
[1] Univ Leuven, Rega Inst, Immunobiol Lab, B-3000 Louvain, Belgium
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 5-6期
关键词：
Arthritis; Cytokines; Adjuvant; Freund; INTERFERON-GAMMA; IFN-GAMMA; MICE LACKING; INDUCTION; RECEPTOR; SUSCEPTIBILITY; IMMUNIZATION; INHIBITION; MECHANISMS; SEVERITY;
D O I：
10.1016/j.cytogfr.2011.11.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we discuss our studies on the pathogenesis of collagen-induced arthritis (CIA) and related mouse models for rheumatoid arthritis. Of note, these models invariably rely on the use of complete Freund's adjuvant (CFA). Our analysis has focused on explaining the dichotomous - either protective or disease-promoting - role of endogenous IFN-gamma. Induction of a myelopoietic burst by CFA was identified as an important and underestimated factor in mediating the role of IFN-gamma and other cytokines (IL-6, IL-17, GCP-2, RANK-L). Myelopoiesis provides an excess in precursors for joint-infiltrating neutrophils and osteoclasts. We postulate that classical CIA is primarily an auto-inflammatory disease, in part because of a strong innate immune response to the adjuvant. Superimposed on this, collagen-specific auto-immunity reinforces inflammatory reactivity in joints. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：339 / 344
页数：6
相关论文
共 33 条
[1]   Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein [J].
Banda, NK ;
Vondracek, A ;
Kraus, D ;
Dinarello, CA ;
Kim, SH ;
Bendele, A ;
Senaldi, G ;
Arend, WP .
JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :2100-2105
[2]   Interferon-γ regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17 [J].
Chu, Cong-Qiu ;
Swart, David ;
Alcorn, Dina ;
Tocker, Joel ;
Elkon, Keith B. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (04) :1145-1151
[3]   IMMUNIZATION AGAINST HETEROLOGOUS TYPE-II COLLAGEN INDUCES ARTHRITIS IN MICE [J].
COURTENAY, JS ;
DALLMAN, MJ ;
DAYAN, AD ;
MARTIN, A ;
MOSEDALE, B .
NATURE, 1980, 283 (5748) :666-668
[4]   Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis [J].
De Klerck, B ;
Carpentier, I ;
Lories, RJ ;
Habraken, Y ;
Piette, J ;
Carmeliet, G ;
Beyaert, R ;
Billiau, A ;
Matthys, P .
ARTHRITIS RESEARCH & THERAPY, 2004, 6 (03) :R220-R231
[5]   Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ [J].
Frey, Oliver ;
Mitera, Tania ;
Kelchtermans, Hilde ;
Schurgers, Evelien ;
Kamradt, Thomas ;
Matthys, Patrick .
JOURNAL OF AUTOIMMUNITY, 2011, 36 (02) :161-169
[6]   Freund's complete adjuvant induces arthritis in mice lacking a functional interferon-γ receptor by triggering tumor necrosis factor α-driven osteoclastogenesis [J].
Geboes, Lies ;
De Klerck, Bert ;
Van Balen, Maarten ;
Ketchtermans, Hilde ;
Mitera, Tania ;
Boon, Louis ;
De Wolf-Peeters, Chris ;
Matthys, Patrick .
ARTHRITIS AND RHEUMATISM, 2007, 56 (08) :2595-2607
[7]   Proinflammatory Role of the Th17 Cytokine Interleukin-22 in Collagen-Induced Arthritis in C57BL/6 Mice [J].
Geboes, Lies ;
Dumoutier, Laure ;
Kelchtermans, Hilde ;
Schurgers, Evelien ;
Mitera, Tania ;
Renauld, Jean-Christophe ;
Matthys, Patrick .
ARTHRITIS AND RHEUMATISM, 2009, 60 (02) :390-395
[8]   Characterization of the adjuvant effect of IL-12 and efficacy of IL-12 inhibitors in type II collagen-induced arthritis [J].
Germann, T ;
Hess, H ;
Szeliga, J ;
Rüde, E .
INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 1996, 795 :227-240
[9]   Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase [J].
Iwanami, Keiichi ;
Matsumoto, Isao ;
Tanaka-Watanabe, Yoko ;
Inoue, Asuka ;
Mihara, Masahiko ;
Ohsugi, Yoshiyuki ;
Mamura, Mizuko ;
Goto, Daisuke ;
Ito, Satoshi ;
Tsutsumi, Akito ;
Kishimoto, Tadamitsu ;
Sumida, Takayuki .
ARTHRITIS AND RHEUMATISM, 2008, 58 (03) :754-763
[10]   Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis:: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ [J].
Kelchtermans, H ;
De Klerck, B ;
Mitera, T ;
Van Balen, M ;
Bullens, D ;
Billiau, A ;
Leclercq, G ;
Matthys, P .
ARTHRITIS RESEARCH & THERAPY, 2005, 7 (02) :R402-R415
1234