Expression of Protein Kinase C Isoforms in Cancerous Breast Tissue and Adjacent Normal Breast Tissue

被引：8

作者：

Lin, Yueh-Min ^{[2
]}

Su, Cheng-Chuan ^{[3
,4
,5
]}

Su, Wei-Wen ^{[6
]}

Hwang, Jin-Ming ^{[7
]}

Hsu, Hsi-Hsien ^{[8
]}

Tsai, Chang-Hai ^{[9
]}

Wang, Yen-Chu ^{[10
]}

Tsai, Fuu-Jen ^{[11
]}

Huang, Chih-Yang ^{[11
,12
,13
]}

Liu, Jer-Yuh ^{[14
,15
]}

Chen, Li-Mien ^{[1
,16
]}

机构：

[1] Armed Force Taichung Gen Hosp, Dept Internal Med, Taichung 40042, Taiwan

[2] Changhua Christian Hosp, Dept Pathol, Changhua 50006, Taiwan

[3] Buddhist Dalin Tzu Chi Gen Hosp, Dept Clin Pathol, Chiayi 62247, Taiwan

[4] Buddhist Dalin Tzu Chi Gen Hosp, Dept Anat Pathol, Chiayi 62247, Taiwan

[5] Tzu Chi Univ, Sch Med, Dept Pathol, Hualien 97002, Taiwan

[6] Changhua Christian Hosp, Comprehens Breast Canc Ctr, Changhua 50006, Taiwan

[7] Chung Shan Med Univ, Sch Appl Chem, Taichung 40201, Taiwan

[8] Mackay Mem Hosp, Div Colorectal Surg, Taipei 10449, Taiwan

[9] Asia Univ, Dept Healthcare Adm, Taichung 41354, Taiwan

[10] Chung Shan Med Univ, Coll Med, Inst Biochem & Biotechol, Taichung 40201, Taiwan

[11] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[12] China Med Univ, Grad Inst Basic Med Sci, Taichung 40402, Taiwan

[13] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

[14] China Med Univ Hosp, Ctr Mol Med, Taichung 40447, Taiwan

[15] China Med Univ, Grad Inst Canc Biol, Taichung 40402, Taiwan

[16] Cent Taiwan Univ Sci & Technol, Ctr Gen Educ, Taichung 40601, Taiwan

来源：

CHINESE JOURNAL OF PHYSIOLOGY | 2012年 / 55卷 / 01期

关键词：

protein kinase C (PKC); human breast cancer; GROWTH-CONTROL; CELL-LINE; ALPHA; ACTIVATION; INHIBITORS; INVASION;

D O I：

10.4077/CJP.2012.AMM118

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The role of protein kinase C (PKC) in the carcinogenesis of human breast tissue has been studied at the molecular level for more than two decades. In this study, we employed Western blotting to determine the presence of PKC isoforms in cancerous and normal breast tissues. The results indicate significant expression of a conventional PKC (PKC alpha) and two atypical PKCs (PKC zeta and lambda/iota) in both breast tumors and adjacent normal breast tissue. For the alpha, zeta and lambda/iota isoforms, the expression of individual isoforms was higher in the breast tumors than in the adjacent normal breast tissue. Although the correlation coefficient was low, significant linear correlation was found among the activities of the isoforms. The data suggest a potential new direction in cancer chemotherapy, namely the blockage of the signal transduction pathway of specific PKC isoforms.

引用

页码：55 / 61

页数：7

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