Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

被引：154

作者：

Gruszczyk, Jakub ^{[1
]}

Kanjee, Usheer ^{[2
]}

Chan, Li-Jin ^{[1
,3
]}

Menant, Sebastien ^{[1
]}

Malleret, Benoit ^{[4
,5
]}

Lim, Nicholas T. Y. ^{[1
]}

Schmidt, Christoph Q. ^{[6
]}

Mok, Yee-Foong ^{[7
]}

Lin, Kai-Min ^{[8
]}

Pearson, Richard D. ^{[9
,10
]}

Rangel, Gabriel ^{[2
]}

Smith, Brian J. ^{[11
]}

Call, Melissa J. ^{[1
,3
]}

Weekes, Michael P. ^{[8
]}

Griffin, Michael D. W. ^{[7
]}

Murphy, James M. ^{[1
,3
]}

Abraham, Jonathan ^{[12
]}

Sriprawat, Kanlaya ^{[13
]}

Menezes, Maria J. ^{[14
]}

Ferreira, Marcelo U. ^{[14
]}

Russell, Bruce ^{[15
]}

Renia, Laurent ^{[5
]}

Duraisingh, Manoj T. ^{[2
]}

Tham, Wai-Hong ^{[1
,3
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

[2] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore 117597, Singapore

[5] ASTAR, Singapore Immunol Network, Singapore 138648, Singapore

[6] Ulm Univ, Inst Pharmacol Nat Prod & Clin Pharmacol, Ulm, Germany

[7] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

[8] Cambridge Inst Med Res, Cambridge CB2 OXY, England

[9] Wellcome Trust Sanger Inst, Cambridge, England

[10] Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England

[11] La Trobe Univ, La Trobe Inst Mol Sci, Melbourne, Vic 3086, Australia

[12] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

[13] Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Fac Trop Med, Mae Sot, Thailand

[14] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, Brazil

[15] Univ Otago, Dept Microbiol & Immunol, Dunedin 9054, New Zealand

来源：

SCIENCE | 2018年 / 359卷 / 6371期

基金：

英国惠康基金; 加拿大健康研究院; 英国医学研究理事会; 美国国家卫生研究院; 澳大利亚研究理事会;

关键词：

HEMORRHAGIC-FEVER ARENAVIRUSES; HUMAN MALARIA PARASITE; ERYTHROCYTE INVASION; CRYSTAL-STRUCTURE; IN-VITRO; FALCIPARUM; DETERMINANTS; MEROZOITES; KNOWLESI; COMPLEX;

D O I：

10.1126/science.aan1078

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition. We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P. vivax but not to invasion of P. falciparum. Using Brazilian and Thai clinical isolates, we show that PvRBP2b monoclonal antibodies that inhibit reticulocyte binding also block P. vivax entry into reticulocytes. These data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.

引用

页码：48 / +

页数：8

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