Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

被引：1285

作者：

van Dam, Gooitzen M. ^{[1
]}

Themelis, George ^{[2
,3
]}

Crane, Lucia M. A. ^{[1
]}

Harlaar, Niels J. ^{[1
,2
,3
]}

Pleijhuis, Rick G. ^{[1
]}

Kelder, Wendy ^{[1
]}

Sarantopoulos, Athanasios ^{[2
,3
]}

de Jong, Johannes S. ^{[1
]}

Arts, Henriette J. G. ^{[4
]}

van der Zee, Ate G. J. ^{[4
]}

Bart, Joost ^{[5
]}

Low, Philip S. ^{[6
]}

Ntziachristos, Vasilis ^{[2
,3
]}

机构：

[1] Univ Groningen, BioOpt Imaging Ctr, Div Surg Oncol, Dept Surg, Groningen, Netherlands

[2] Tech Univ Munich, Munich, Germany

[3] Helmholtz Zentrum, Munich, Germany

[4] Univ Groningen, Div Gynaecol Oncol, Dept Gynaecol, Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Mol Biol, Groningen, Netherlands

[6] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 10期

关键词：

SURGERY; EXPRESSION; MANAGEMENT; SURVIVAL; FUTURE; MODEL;

D O I：

10.1038/nm.2472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

引用

页码：1315 / U202

页数：6

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