Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip

被引：2

作者：

Riquelme-Guzman, Camilo ^{[1
]}

Contreras, Osvaldo ^{[2
,3
]}

机构：

[1] Tech Univ Dresden, CRTD Ctr Regenerat Therapies Dresden, D-01307 Dresden, Germany

[2] Victor Chang Cardiac Res Inst, Dev & Stem Cell Biol Div, Darlinghurst, NSW 2010, Australia

[3] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Santiago 8331150, Chile

来源：

DEVELOPMENTAL BIOLOGY | 2020年 / 461卷 / 02期

关键词：

Regeneration; PDGFRA; Wound healing; MSCs; Epimorphic regeneration; Fibroblasts; Mesenchymal progenitors; Repair; Blastema; CHOREOGRAPHY; PROGENITOR;

D O I：

10.1016/j.ydbio.2020.02.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema remain unknown. In an exciting new work, Storer et al. take advantage of single-cell RNAseq combined with Pdgfra+ lineage-tracing to open the way into the enigmatic world of mammalian tissue regeneration.

引用

页码：107 / 109

页数：3