Vaccination of cattle only is sufficient to stop FMDV transmission in mixed populations of sheep and cattle

被引:14
作者
De Rueda, C. Bravo [1 ]
Dekker, A. [1 ]
Eble, P. L. [1 ]
De Jong, M. C. M. [2 ]
机构
[1] Wageningen UR, Cent Vet Inst, NL-8200 AB Lelystad, Netherlands
[2] Wageningen Univ, Dept Quantitat Vet Epidemiol, NL-6700 AP Wageningen, Netherlands
关键词
Cattle-sheep populations; foot-and-mouth disease virus; NGM; targeted vaccination; transmission; MOUTH-DISEASE VIRUS; BASIC REPRODUCTION RATIO; BETWEEN-PEN TRANSMISSION; EMERGENCY VACCINATION; INFECTIOUS-DISEASES; QUANTIFICATION; ERADICATION; PROTECTION; EXPOSURE; EUROPE;
D O I
10.1017/S0950268814003033
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We quantified the transmission of foot-and-mouth disease virus in mixed cattle-sheep populations and the effect of different vaccination strategies. The (partial) reproduction ratios (R) in groups of non-vaccinated and vaccinated cattle and/or sheep were estimated from (published) transmission experiments. A 4 x 4 next-generation matrix (NGM) was constructed using these estimates. The dominant eigenvalue of the NGM, the R for a mixed population, was determined for populations with different proportions of cattle and sheep and for three different vaccination strategies. The higher the proportion of cattle in a mixed cattle-sheep population, the higher the R for the mixed population. Therefore the impact of vaccination of the cattle is higher. After vaccination of all animals R = 0.1 independent of population composition. In mixed cattle-sheep populations with at least 14% of cattle, vaccination of cattle only is sufficient to reduce R to < 1.
引用
收藏
页码:2279 / 2286
页数:8
相关论文
共 35 条
[1]  
ANDERSON R M, 1991
[2]   THE INVASION, PERSISTENCE AND SPREAD OF INFECTIOUS-DISEASES WITHIN ANIMAL AND PLANT-COMMUNITIES [J].
ANDERSON, RM ;
MAY, RM .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1986, 314 (1167) :533-570
[3]  
Becker N.G., 1989, ANAL INFECT DIS DATA
[4]   Further evaluation of higher potency vaccines for early protection of cattle against FMDV direct contact challenge [J].
Cox, Sarah J. ;
Parida, Satya ;
Voyce, Charlotte ;
Reid, Scott A. ;
Hamblin, Pip A. ;
Hutchings, Geoff ;
Paton, David J. ;
Barnett, Paul V. .
VACCINE, 2007, 25 (44) :7687-7695
[5]   Emergency vaccination of sheep against foot-and-mouth disease: protection against disease and reduction in contact transmission [J].
Cox, SJ ;
Barnett, PV ;
Dani, P ;
Salt, JS .
VACCINE, 1999, 17 (15-16) :1858-1868
[6]   Estimation of the transmission of foot-and-mouth disease virus from infected sheep to cattle [J].
de Rueda, Carla Bravo ;
de Jong, Mart C. M. ;
Eble, Phaedra L. ;
Dekker, Aldo .
VETERINARY RESEARCH, 2014, 45
[7]   EXPERIMENTAL QUANTIFICATION OF VACCINE-INDUCED REDUCTION IN VIRUS TRANSMISSION [J].
DEJONG, MCM ;
KIMMAN, TG .
VACCINE, 1994, 12 (08) :761-766
[8]   The construction of next-generation matrices for compartmental epidemic models [J].
Diekmann, O. ;
Heesterbeek, J. A. P. ;
Roberts, M. G. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2010, 7 (47) :873-885
[9]  
DIEKMANN O, 1990, J MATH BIOL, V28, P365
[10]  
Donaldson A., 2000, SESS RES GROUP STAND