Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues

被引：26
作者：
Yin, Tiejun [1 ]
Yu, Shiying [2 ]
Xiao, Liang [1 ]
Zhang, Jun [1 ]
Liu, Chong [3 ]
Lu, Yunping [4 ]
Liu, Chengping [5 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Comprehens Med, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Dept Oncol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Dept Pathol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
[4] Huazhong Univ Sci & Technol, Dept Obstet & Gynecol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
[5] Huazhong Univ Agr, Dept Math, Wuhan 430070, Peoples R China
来源：
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2008年 / 28卷 / 03期
关键词：
aquaporin; 1; hypoxia-inducible factor 1; breast cancer; correlation;
D O I：
10.1007/s11596-008-0327-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The correlation between aquaporin 1 (AQP1) and hypoxia-inducible factor 1 (HIF 1) in breast cancer tissues was preliminarily studied. In 155 cases of breast cancer, the expression levels of AQP1 were detected by immunohistochemisty in HIF1-positive group or HIF1-negative group, and the correlation between AQP1 and HIF1 was analyzed. The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues. The expression level of AQP1 in HIF1-positive group was significantly higher than that in HIF1-negative group. The positive expression rate of AQP1 was 296.55 +/- 24.67 and 168.37 +/- 37.53 in HIF1-positive group and HIF1-negative group respectively with the difference being very significant between them (P < 0.001). It was concluded that AQP1 was overexpressed in the HIF1-positive group and there were some correlations between AQP1 and HIF1, suggesting they interact each other and regulate the oncogenesis of breast cancer.
引用
收藏
页码：346 / 348
页数：3
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