Palladium-Catalyzed One-Pot Synthesis of N-Sulfonyl, N-Phosphoryl, and N-Acyl Guanidines

被引：17

作者：

Qiao, Guanyu ^{[1
]}

Zhang, Zhen ^{[1
]}

Huang, Baoliang ^{[1
]}

Zhu, Liu ^{[1
]}

Xiao, Fan ^{[1
]}

Zhang, Zhenhua ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, West Yuanmingyuan Rd 2, Beijing 100193, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 02期

基金：

中国国家自然科学基金;

关键词：

sulfones; phosphorus; azides; functionalized guanidines; palladium catalysis; ORGANIC AZIDES; C-H; 3-COMPONENT REACTION; NITRENE TRANSFER; CARBODIIMIDES; CARBONYLATION; AMIDINES; CYCLOADDITION; DECOMPOSITION; ISOCYANIDES;

D O I：

10.1055/s-0036-1588576

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed cascade reaction of azides with isonitrile and amines is presented; it offers an alternative facile approach toward N-sulfonyl-, N-phosphoryl-, and N-acyl-functionalized guanidines in excellent yield. These series of substituted guanidines exhibit potential biological and pharmacological activities. In addition, the less reactive intermediate benzoyl carbodiimide could be isolated by silica gel column flash chromatography in moderate yield.

引用

页码：330 / 340

页数：11

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