The Role of Tumor Associated Macrophages (TAMs) in Cancer Pro-gression, Chemoresistance, Angiogenesis and Metastasis-Current Status

被引：154

作者：

Dallavalasa, Siva ^{[1
]}

Beeraka, Narasimha M. ^{[1
]}

Basavaraju, Chaithanya G. ^{[1
]}

Tulimilli, SubbaRao, V ^{[1
]}

Sadhu, Surya Prabha ^{[2
]}

Rajesh, Konathala ^{[3
]}

Aliev, Gjumrakch ^{[4
,5
,6
,7
]}

Madhunapantula, SubbaRao, V ^{[1
,8
]}

机构：

[1] JSS Acad Higher Educ & Res JSS AHER, JSS Med Coll, Ctr Excellence Mol Biol & Regenerat Med CEMR, Dept Biochem, Mysuru 570015, Karnataka, India

[2] Andhra Univ, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

[3] Kakinada Inst Technol Sci KITS, Ramachandrapuram 533255, Andhra Pradesh, India

[4] Sechenov First Moscow State Med Univ, Sechenov Univ, St Trubetskaya 8,Bld 2, Moscow 119991, Russia

[5] Russian Acad Sci, Inst Physiologically Act Cpds, Chernogolovka 142432, Moscow Region, Russia

[6] Res Inst Human Morphol, 3 Tsyurupy St, Moscow 117418, Russia

[7] GALLY Int Res Inst, 7733 Louis Pasteur Dr,330, San Antonio, TX 78229 USA

[8] JSS Acad Higher Educ & Res JSS AHER, Special Interest Grp Canc Biol & Canc Stem Cells, Mysuru 570015, Karnataka, India

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 39期

关键词：

target TAMs using multi-OMICs approaches; including genomics; epigenomics; tran-; Tumor associated macrophages; tumor microenvironment; chemosensitization; tumor angiogenesis; EPITHELIAL-MESENCHYMAL TRANSITION; CELL LUNG-CANCER; ALTERNATIVELY-ACTIVATED MACROPHAGES; HUMAN PROSTATE-CANCER; C-REACTIVE PROTEIN; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; OVARIAN-CANCER; EXTRACELLULAR-MATRIX;

D O I：

10.2174/0929867328666210720143721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor associated macrophages (TAMs), located in the tumor microenvironment (TME), play a significant role in cancer cell survival and progression. TAMs have been involved in producing immuno-suppressive TME in the tumor by generating inflammatory mediators, growth factors, cytokines, chemokines, etc. TAMs can influence the angiogenesis, metastatic behavior of tumor cells (TCs) and cause multidrug resistance. TAMs within the TME can enhance cancer cell metastasis and are stromal and perivascular. The angiogenesis is promoted at the hypoxia, and the avascular zones of TME. Differentiation states of TAMs are considered 'plastic' as they exhibit temporal expression of one or several phenotypes depending on local cues. Emerging cancer research depicted the epigenetic regulation of macrophage polarization (both M1s, M2s) and their potential implications to develop pharmacologic modulators and microRNAs to act as molecular switches and even to serve as targeted therapies to inhibit tumor growth. In the present article, the role of TAMs in tumor progression, angiogenesis and metastasis was discussed. In addition, key signaling cascades regulated by TAMs, which have a role in chemoresistance, were also discussed. Currently, novel pleiotropic properties of various anticancer phytomedicines are gaining importance as they assist in overcoming TAMs-induced chemoresistance. Moreover, these phytomedicines are being tested as 'adjunct therapeutics' along with chemotherapeutic agents, anti-angiogenic molecules, anti-metastatic compounds, and other immune-checkpoint blockers against tumor metastasis/angiogenesis. Hence, a brief note on natural products targeting TAMs was provided. In summary, this review would benefit pharmacologists and medical professionals to develop therapies to scriptomics, and proteomics.

引用

页码：8203 / 8236

页数：34

共 315 条

[51] Tumor-Associated Macrophages Mediate Immunosuppression in the Renal Cancer Microenvironment by Activating the 15-Lipoxygenase-2 Pathway [J].