Colorectal Hamartomatous Polyposis and Ganglioneuromatosis in a Dog

被引：16

作者：

Bemelmans, I. ^{[1
,2
]}

Kuery, S. ^{[3
,4
]}

Albaric, O. ^{[1
,2
]}

Hordeaux, J. ^{[1
,2
]}

Bertrand, L. ^{[1
,2
]}

Nguyen, F. ^{[1
,2
]}

Abadie, J. ^{[1
,2
]}

机构：

[1] ONIRIS, Dept Pathol, F-44307 Nantes, France

[2] Univ Nantes Angers Le Mans, Le Mans, France

[3] Univ Rennes 1, Inst Genet & Dev, Fac Med, Rennes, France

[4] CHU Nantes, Serv Genet Med, F-44035 Nantes 01, France

来源：

VETERINARY PATHOLOGY | 2011年 / 48卷 / 05期

关键词：

colon; Cowden syndrome; dog; ganglioneuromatosis; hamartoma; immunohistochemistry; polyp; PTEN;

D O I：

10.1177/0300985810384411

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 5-month-old female Great Dane puppy was treated for hematochezia, tenesmus, and rectal prolapse by resection of a 10-cm-long segment of colon and rectum. Grossly, the colorectal segment had diffuse mucosal and submucosal thickening with multiple polypoid nodules. The histologic diagnosis was colorectal hamartomatous polyps with ganglioneuromatosis. Duplication of PTEN was detected by quantitative multiplex polymerase chain reaction testing. The presence of 2 hamartomatous colorectal lesions with PTEN mutation is similar to human Cowden syndrome.

引用

页码：1012 / 1015

页数：4

共 15 条

[1] Gastrointestinal polyposis syndromes [J].

Bronner, MP .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 122A (04) :335-341

[2]

Brown CC, 2007, Jubb, Kennedy and Palmer's pathology of domestic animals, V2, P1

[3] Genetics of the hamartomatous polyposis syndromes: a molecular review [J].

Chen, Hui-Min ;

Fang, Jing-Yuan .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2009, 24 (08) :865-874

[4] Mapping DNA structural variation in dogs [J].

Chen, Wei-Kang ;

Swartz, Joshua D. ;

Rush, Laura J. ;

Alvarez, Carlos E. .

GENOME RESEARCH, 2009, 19 (03) :500-509

[5] COLORECTAL GANGLIONEUROMATOSIS IN A YOUNG FEMALE DOG (LHASA-APSO) [J].

FAIRLEY, RA ;

MCENTEE, MF .

VETERINARY PATHOLOGY, 1990, 27 (03) :206-207

[6] HEREDITARY GASTROINTESTINAL POLYPOSIS SYNDROMES [J].

HAGGITT, RC ;

REID, BJ .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1986, 10 (12) :871-887

[7] Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value [J].

Jardin, Fabrice ;

Picquenot, Jean-Michel ;

Parmentier, Francoise ;

Ruminy, Philippe ;

Cornic, Marie ;

Penther, Dominique ;

Bertrand, Philippe ;

Lanic, Helene ;

Cassuto, Ophelie ;

Humbrecht, Catherine ;

Lemasle, Emilie ;

Wautier, Agathe ;

Bastard, Christian ;

Tilly, Herve .

BRITISH JOURNAL OF HAEMATOLOGY, 2009, 146 (06) :607-618

[8] FAMILIAL GANGLIONEUROMATOUS POLYPOSIS OF THE LARGE BOWEL - REPORT OF A FAMILY WITH ASSOCIATED JUVENILE POLYPOSIS [J].

MENDELSOHN, G ;

DIAMOND, MP .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1984, 8 (07) :515-520

[9] Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome [J].

Orloff, M. S. ;

Eng, C. .

ONCOGENE, 2008, 27 (41) :5387-5397

[10]

PHAM BN, 1989, ARCH PATHOL LAB MED, V113, P91

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