Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells

被引：36
作者：
Wakaki, H
Sakamoto, H
Awazu, M
机构：
[1] Keio Univ, Sch Med, Dept Pediat, Shinjuku Ku, Tokyo 1608582, Japan
[2] Tokyo Med & Dent Univ, Dept Internal Med 2, Tokyo 1608582, Japan
来源：
PEDIATRICS | 2001年 / 107卷 / 06期
关键词：
tubulointerstitial nephritis; uveitis; antibody; kidney; renal tubule; hypergamma-globulinemia;
D O I：
10.1542/peds.107.6.1443
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The pathogenesis of tubulointerstitial nephritis and uveitis (TINU) syndrome remains unknown, but T cell-mediated immune response has been postulated to play a role. On the other hand, TINU syndrome is characterized by hypergammaglobulinemia and high serum immunoglobulin G (IgG) levels, suggesting an involvement of humoral immunity. We describe a case of TINU syndrome in a 13-year-old girl with multiple tubular dysfunctions including renal glucosuria, tubular proteinuria, phosphaturia, uricosuria, and concentrating and acidifying defect. IgG antibody from her serum was reactive against 125-kDa human kidney protein. Immunofluorescence study using mouse kidney revealed that the antibody was against cortical renal tubular cells. The antibody disappeared as the renal symptoms resolved. We suggest that IgG antibody may contribute to tubular dysfunction in some patients with TINU syndrome.
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收藏
页码：1443 / 1446
页数：4
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