Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

被引：142

作者：

Chang, John T. ^{[1
,2
]}

Ciocca, Maria L. ^{[1
,2
]}

Kinjyo, Ichiko ^{[1
,2
]}

Palanivel, Vikram R. ^{[1
,2
]}

McClurkin, Courtney E. ^{[1
,2
]}

De Jong, Caitlin S. ^{[1
,2
]}

Mooney, Erin C. ^{[1
,2
]}

Kim, Jiyeon S. ^{[1
,2
]}

Steinel, Natalie C. ^{[1
,2
]}

Oliaro, Jane ^{[3
]}

Yin, Catherine C. ^{[4
]}

Florea, Bogdan I. ^{[5
]}

Overkleeft, Herman S. ^{[5
]}

Berg, Leslie J. ^{[4
]}

Russell, Sarah M. ^{[3
,6
]}

Koretzky, Gary A. ^{[1
,2
,7
]}

Jordan, Martha S. ^{[7
]}

Reiner, Steven L. ^{[1
,2
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[3] Peter MacCallum Canc Ctr, Immune Signalling Lab, Melbourne, Vic 2002, Australia

[4] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

[5] Leiden Univ, NL-2333 CC Leiden, Netherlands

[6] Swinburne Univ Technol, Fac Engn & Ind Sci, Ctr MicroPhoton, Hawthorn, Vic 3122, Australia

[7] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2011年 / 34卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

IMMUNOLOGICAL SYNAPSE; LINEAGE COMMITMENT; CELL-DIVISION; DIFFERENTIATION; KINASE; EXPRESSION; EFFECTOR; GAMMA; CD4; ITK;

D O I：

10.1016/j.immuni.2011.03.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells.

引用

页码：492 / 504

页数：13

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