Brief Report: Low Incidence of Hepatitis C Among a Cohort of HIV-Negative Gay and Bisexual Men Using HIV Pre-exposure Prophylaxis (PrEP) in Melbourne, Australia, and the Contribution of Sexual Transmission

被引:7
作者
Cornelisse, Vincent J. [1 ,2 ,3 ,4 ]
Traeger, Michael W. [5 ,6 ]
Wright, Edwina J. [1 ,2 ,5 ,7 ]
Murphy, Dean [4 ,8 ]
Stoove, Mark [5 ,6 ,9 ]
Hellard, Margaret [1 ,5 ]
Sacks-Davis, Rachel [5 ,6 ]
Asselin, Jason [5 ]
Fairley, Christopher K. [1 ,3 ]
Doyle, Joseph [1 ,2 ,5 ]
Sasadeusz, Joseph [2 ,7 ,10 ]
机构
[1] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia
[2] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia
[3] Alfred Hlth, Melbourne Sexual Hlth Ctr, Melbourne, Vic, Australia
[4] UNSW, Kirby Inst, Sydney, NSW, Australia
[5] Burnet Inst, Prahran, Vic, Australia
[6] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
[7] Univ Melbourne, Doherty Inst Infect & Immun, Melbourne, Vic, Australia
[8] Univ Sydney, Dept Gender & Cultural Studies, Sydney, NSW, Australia
[9] La Trobe Univ, Sch Psychol & Publ Hlth, Bundoora, Vic, Australia
[10] Royal Melbourne Hosp, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
hepatitis C; pre-exposure prophylaxis; HIV; homosexuality; male; disease transmission; infectious; sexually transmitted diseases; viral; substance abuse; VIRUS-INFECTION; POSITIVE MEN; HIGH-RISK; MSM;
D O I
10.1097/QAI.0000000000002685
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: PrEPX was an Australian HIV pre-exposure prophylaxis (PrEP) study conducted between 2016 and 2018. This analysis aimed to estimate hepatitis C (HCV) incidence and explore likely modes of transmission. Setting: Cohort study of PrEP users in Victoria, Australia. Methods: HCV tests were conducted at enrollment and every 12 months thereafter. HCV incident cases were identified from laboratory data. Likely modes of transmission were inferred from computer-assisted self-interviews, medical records, and interviews. Results: Among 3202 PrEPX participants tested for HCV at baseline, HCV RNA-positive prevalence was 0.22% (95% confidence interval: 0.09 to 0.45). Among participants testing HCV antibody-negative or RNA-negative at baseline, 2058 had at least one follow-up HCV test. Eight incident HCV cases were identified during 2111 person-years of follow-up (incidence 0.38/100 person-years); all were primary infections in men who had sex with men. Clinical, laboratory, and computer-assisted self-interviews data were available for all, and 6 cases were interviewed. Three cases were attributable to injecting drug use (IDU). A fourth case reported IDU, but his HCV was attributable to sexual transmission. Four other cases reported no IDU and probably acquired HCV sexually. Most cases reported anal trauma in the context of condomless receptive anal intercourse during group sex at sex-on-premises venues. Conclusions: In PrEPX, HCV incidence was low compared to international PrEP studies, and most cases were transmitted sexually. Our findings highlight the need for HCV prevention messaging by clinicians, in sex-on-premises venues, and on digital platforms used to arrange group sex; and the need for HCV screening among some PrEP-using men who have sex with men.
引用
收藏
页码:1011 / 1015
页数:5
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