Association studies in thyroid cancer susceptibility: are we on the right track?

被引：47

作者：

Landa, Inigo ^{[1
]}

Robledo, Mercedes ^{[1
,2
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Hereditary Endocrine Canc Grp, Madrid 28029, Spain

[2] CIBERER, Madrid, Spain

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2011年 / 47卷 / 01期

关键词：

S-TRANSFERASE POLYMORPHISMS; SINGLE NUCLEOTIDE POLYMORPHISMS; RET PROTOONCOGENE; GENETIC MODIFIERS; INCREASING INCIDENCE; OVER-REPRESENTATION; SEQUENCE VARIANT; DEGREE RELATIVES; LINKAGE ANALYSIS; INCREASED RISK;

D O I：

10.1530/JME-11-0005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is widely accepted that thyroid cancer is strongly determined by the individual genetic background. In this regard, it is expected that sporadic thyroid cancer is the result of multiple low-to moderate-penetrance genes interacting with each other and with the environment, thus modulating individual susceptibility. In the last years, an important number of association studies on thyroid cancer have been published, trying to determine this genetic contribution. The aim of this review is to provide a comprehensive and critical evaluation of the associations reported so far in thyroid cancer susceptibility in case-control studies performed in both non-medullary (papillary and follicular) and medullary thyroid cancers, including their potential strengths and pitfalls. We summarize the genetic variants reported to date, and stress the importance of validating the results in independent series and assessing the functional role of the associated loci.

引用

页码：R43 / R58

页数：16

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