Surface Functionalization of Magnetite Nanoparticles with Multipotent Antioxidant as Potential Magnetic Nanoantioxidants and Antimicrobial Agents

被引：15

作者：

Shah, Syed Tawab ^{[1
]}

Chowdhury, Zaira Zaman ^{[1
]}

Johan, Mohd. Rafie Bin ^{[1
]}

Badruddin, Irfan Anjum ^{[2
,3
]}

Khaleed, H. M. T. ^{[4
]}

Kamangar, Sarfaraz ^{[2
]}

Alrobei, Hussein ^{[5
]}

机构：

[1] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Kuala Lumpur 50603, Malaysia

[2] King Khalid Univ, Coll Engn, Dept Mech Engn, Abha 61421, Saudi Arabia

[3] King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, Abha 61413, Saudi Arabia

[4] Islamic Univ Madinah, Fac Engn, Dept Mech Engn, Medina 42351, Saudi Arabia

[5] Prince Sattam Bin Abdulaziz Univ, Fac Engn, Dept Mech Engn, Al Kharj 16278, Saudi Arabia

来源：

MOLECULES | 2022年 / 27卷 / 03期

关键词：

functionalization; magnetite nanoparticles; nanoantioxiants; FE3O4;

D O I：

10.3390/molecules27030789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine.

引用

页数：17