Surface Functionalization of Magnetite Nanoparticles with Multipotent Antioxidant as Potential Magnetic Nanoantioxidants and Antimicrobial Agents

被引:13
作者
Shah, Syed Tawab [1 ]
Chowdhury, Zaira Zaman [1 ]
Johan, Mohd. Rafie Bin [1 ]
Badruddin, Irfan Anjum [2 ,3 ]
Khaleed, H. M. T. [4 ]
Kamangar, Sarfaraz [2 ]
Alrobei, Hussein [5 ]
机构
[1] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Kuala Lumpur 50603, Malaysia
[2] King Khalid Univ, Coll Engn, Dept Mech Engn, Abha 61421, Saudi Arabia
[3] King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, Abha 61413, Saudi Arabia
[4] Islamic Univ Madinah, Fac Engn, Dept Mech Engn, Medina 42351, Saudi Arabia
[5] Prince Sattam Bin Abdulaziz Univ, Fac Engn, Dept Mech Engn, Al Kharj 16278, Saudi Arabia
来源
MOLECULES | 2022年 / 27卷 / 03期
关键词
functionalization; magnetite nanoparticles; nanoantioxiants; FE3O4;
D O I
10.3390/molecules27030789
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine.
引用
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页数:17
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