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Surface Functionalization of Magnetite Nanoparticles with Multipotent Antioxidant as Potential Magnetic Nanoantioxidants and Antimicrobial Agents
被引:13
作者:
Shah, Syed Tawab
[1
]
Chowdhury, Zaira Zaman
[1
]
Johan, Mohd. Rafie Bin
[1
]
Badruddin, Irfan Anjum
[2
,3
]
Khaleed, H. M. T.
[4
]
Kamangar, Sarfaraz
[2
]
Alrobei, Hussein
[5
]
机构:
[1] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Kuala Lumpur 50603, Malaysia
[2] King Khalid Univ, Coll Engn, Dept Mech Engn, Abha 61421, Saudi Arabia
[3] King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, Abha 61413, Saudi Arabia
[4] Islamic Univ Madinah, Fac Engn, Dept Mech Engn, Medina 42351, Saudi Arabia
[5] Prince Sattam Bin Abdulaziz Univ, Fac Engn, Dept Mech Engn, Al Kharj 16278, Saudi Arabia
来源:
MOLECULES
|
2022年
/
27卷
/
03期
关键词:
functionalization;
magnetite nanoparticles;
nanoantioxiants;
FE3O4;
D O I:
10.3390/molecules27030789
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine.
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页数:17