Versatile coordination behavior of N,N-di(alkyl/aryl)-N′-benzoylthiourea ligands: Synthesis, crystal structure and cytotoxicity of palladium(II) complexes

被引：72

作者：

Selvakumaran, N. ^{[1
]}

Ng, Seik Weng ^{[2
]}

Tiekink, Edward R. T. ^{[2
]}

Karvembu, R. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Tiruchirappalli 620015, Tamil Nadu, India

[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

来源：

INORGANICA CHIMICA ACTA | 2011年 / 376卷 / 01期

关键词：

Palladium(II); Thiourea; Synthesis; X-ray structures; Anti-cancer activity; PLATINUM(II) ORGANOMETALLIC COMPLEXES; SOLVENT-EXTRACTION; FLUOROMETRIC DETECTION; MOLECULAR-STRUCTURES; MAGNETIC-PROPERTIES; ANTITUMOR-ACTIVITY; COPPER(II); METALS; DNA; DERIVATIVES;

D O I：

10.1016/j.ica.2011.06.031

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of Pd(II) complexes with the general formula cis-[Pd(L-O,S)(2)] (HL = N,N-diethyl-N'-benzoylthiourea, N,N-diisobutyl-N'-benzoylthiourea or N,N-dibenzyl-N'-benzoylthiourea) and trans-[PdCl2(HL-S)(2)] (HL = N,N-diphenyl-N'-benzoylthiourea, N,N-di-n-butyl-N'-benzoylthiourea or N,N-diisopropyl-N'-benzoylthiourea) are reported. These complexes were formed from the reaction between PdCl2 and N,N-di(alky/aryl)-N'-benzoylthiourea in acetonitrile with the formulation dependent on the nature of HL. The new Pd(II) complexes have been characterized by analytical and spectral (FT-IR, UV-Vis, H-1 NMR and C-13 NMR, Mass) techniques. The molecular structures of two of the complexes (1 and 5) have been conformed by X-ray crystallography. Complex 1 shows cytotoxicity against human breast cancer cells. (C) 2011 Elsevier B. V. All rights reserved.

引用

页码：278 / 284

页数：7

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