COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

被引：28

作者：

Chakrabarti, Sankha Shubhra ^{[1
]}

Kaur, Upinder ^{[2
]}

Banerjee, Anindita ^{[3
]}

Ganguly, Upasana ^{[3
]}

Banerjee, Tuhina ^{[4
]}

Saha, Sarama ^{[5
]}

Parashar, Gaurav ^{[6
]}

Prasad, Suvarna ^{[7
]}

Chakrabarti, Suddhachitta ^{[8
]}

Mittal, Amit ^{[9
]}

Agrawal, Bimal Kumar ^{[10
]}

Rawal, Ravindra Kumar ^{[11
]}

Zhao, Robert Chunhua ^{[12
]}

Gambhir, Indrajeet Singh ^{[1
]}

Khanna, Rahul ^{[13
]}

Shetty, Ashok K. ^{[14
]}

Jin, Kunlin ^{[15
]}

Chakrabarti, Sasanka ^{[16
]}

机构：

[1] Banaras Hindu Univ, Inst Med Sci, Dept Geriatr Med, Varanasi, Uttar Pradesh, India

[2] All India Inst Med Sci, Dept Pharmacol, Gorakhpur, Uttar Pradesh, India

[3] Inst Post Grad Med Educ & Res, Dept Biochem, Kolkata, W Bengal, India

[4] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi, Uttar Pradesh, India

[5] All India Inst Med Sci, Dept Biochem, Rishikesh, Uttarakhand, India

[6] Maharishi Markandeshwar Deemed Be Univ, Dept Biotechnol, Mullana, Haryana, India

[7] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Biochem, Mullana, Haryana, India

[8] Kolkata Municipal Corp, Hlth Dept, Kolkata, India

[9] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Radiodiag, Mullana, Haryana, India

[10] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Gen Med, Mullana, Haryana, India

[11] Maharishi Markandeshwar Deemed Be Univ, Dept Chem, Mullana, Haryana, India

[12] Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China

[13] Banaras Hindu Univ, Inst Med Sci, Dept Gen Surg, Varanasi, Uttar Pradesh, India

[14] Texas A&M Univ, Coll Med, Dept Mol & Cellular Med, Inst Regenerat Med, College Stn, TX 77843 USA

[15] Univ North Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA

[16] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Biochem & Cent Res Cell, Mullana, Haryana, India

来源：

AGING AND DISEASE | 2020年 / 11卷 / 03期

关键词：

COVID-19; India; transmission; mortality; ACE2; cross-immunity; HUMAN CORONAVIRUSES; ANTIBODIES;

D O I：

10.14336/AD.2020.0402

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.

引用

页码：480 / 488

页数：9

共 23 条

[21] Morvan's syndrome-is a pathogen behind the curtain? [J].

Singh, Rohit ;

Das, Pritam ;

Kaur, Upinder ;

Misra, Anamika ;

Choudhury, Ashis ;

Manna, Sukdev ;

Gaude, Rohit ;

Gautam, Deepak ;

Gambhir, Indrajeet Singh ;

Chakrabarti, Sankha Shubhra .

NEUROLOGICAL SCIENCES, 2018, 39 (11) :1965-1969

[22]

van der Hoek L, 2007, ANTIVIR THER, V12, P651

[23] Human poly- and cross-reactive anti-viral antibodies and their impact on protection and pathology [J].

Warter, Lucile ;

Appanna, Ramapraba ;

Fink, Katja .

IMMUNOLOGIC RESEARCH, 2012, 53 (1-3) :148-161

← 1 2 3 →