COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

被引：28

作者：

Chakrabarti, Sankha Shubhra ^{[1
]}

Kaur, Upinder ^{[2
]}

Banerjee, Anindita ^{[3
]}

Ganguly, Upasana ^{[3
]}

Banerjee, Tuhina ^{[4
]}

Saha, Sarama ^{[5
]}

Parashar, Gaurav ^{[6
]}

Prasad, Suvarna ^{[7
]}

Chakrabarti, Suddhachitta ^{[8
]}

Mittal, Amit ^{[9
]}

Agrawal, Bimal Kumar ^{[10
]}

Rawal, Ravindra Kumar ^{[11
]}

Zhao, Robert Chunhua ^{[12
]}

Gambhir, Indrajeet Singh ^{[1
]}

Khanna, Rahul ^{[13
]}

Shetty, Ashok K. ^{[14
]}

Jin, Kunlin ^{[15
]}

Chakrabarti, Sasanka ^{[16
]}

机构：

[1] Banaras Hindu Univ, Inst Med Sci, Dept Geriatr Med, Varanasi, Uttar Pradesh, India

[2] All India Inst Med Sci, Dept Pharmacol, Gorakhpur, Uttar Pradesh, India

[3] Inst Post Grad Med Educ & Res, Dept Biochem, Kolkata, W Bengal, India

[4] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi, Uttar Pradesh, India

[5] All India Inst Med Sci, Dept Biochem, Rishikesh, Uttarakhand, India

[6] Maharishi Markandeshwar Deemed Be Univ, Dept Biotechnol, Mullana, Haryana, India

[7] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Biochem, Mullana, Haryana, India

[8] Kolkata Municipal Corp, Hlth Dept, Kolkata, India

[9] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Radiodiag, Mullana, Haryana, India

[10] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Gen Med, Mullana, Haryana, India

[11] Maharishi Markandeshwar Deemed Be Univ, Dept Chem, Mullana, Haryana, India

[12] Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China

[13] Banaras Hindu Univ, Inst Med Sci, Dept Gen Surg, Varanasi, Uttar Pradesh, India

[14] Texas A&M Univ, Coll Med, Dept Mol & Cellular Med, Inst Regenerat Med, College Stn, TX 77843 USA

[15] Univ North Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA

[16] Maharishi Markandeshwar Deemed Be Univ, MM Inst Med Sci & Res, Dept Biochem & Cent Res Cell, Mullana, Haryana, India

来源：

AGING AND DISEASE | 2020年 / 11卷 / 03期

关键词：

COVID-19; India; transmission; mortality; ACE2; cross-immunity; HUMAN CORONAVIRUSES; ANTIBODIES;

D O I：

10.14336/AD.2020.0402

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.

引用

页码：480 / 488

页数：9

共 23 条

[1]

[Anonymous], JAMA

[2]

[Anonymous], 001586 BIORXIV

[3]

[Anonymous], HIGH TEMPERATURE HIG

[4] Present and future Koppen-Geiger climate classification maps at 1-km resolution [J].

Beck, Hylke E. ;

Zimmermann, Niklaus E. ;

McVicar, Tim R. ;

Vergopolan, Noemi ;

Berg, Alexis ;

Wood, Eric F. .

SCIENTIFIC DATA, 2018, 5

[5] Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations [J].

Cao, Yanan ;

Li, Lin ;

Feng, Zhimin ;

Wan, Shengqing ;

Huang, Peide ;

Sun, Xiaohui ;

Wen, Fang ;

Huang, Xuanlin ;

Ning, Guang ;

Wang, Weiqing .

CELL DISCOVERY, 2020, 6 (01)

[6] Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests [J].

Chan, Kwok-Hung ;

Chan, Jasper Fuk-Woo ;

Tse, Herman ;

Chen, Honglin ;

Lau, Candy Choi-Yi ;

Cai, Jian-Piao ;

Tsang, Alan Ka-Lun ;

Xiao, Xincai ;

To, Kelvin Kai-Wang ;

Lau, Susanna Kar-Pui ;

Woo, Patrick Chiu-Yat ;

Zheng, Bo-Jiang ;

Wang, Ming ;

Yuen, Kwok-Yung .

JOURNAL OF INFECTION, 2013, 67 (02) :130-140

[7] Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43 [J].

Che, XY ;

Qiu, LW ;

Liao, ZY ;

Wang, YD ;

Wen, K ;

Pan, YX ;

Hao, W ;

Mei, YB ;

Cheng, VCC ;

Yuen, KY .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (12) :2033-2037

[8]

Clark Ian A, 2008, Travel Med Infect Dis, V6, P67, DOI 10.1016/j.tmaid.2007.07.002

[9]

Fehr AR, 2015, METHODS MOL BIOL, V1282, P1, DOI 10.1007/978-1-4939-2438-7_1

[10] The first two cases of 2019-nCoV in Italy: Where they come from? [J].

Giovanetti, Marta ;

Benvenuto, Domenico ;

Angeletti, Silvia ;

Ciccozzi, Massimo .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (05) :518-521

← 1 2 3 →