Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors

被引:122
作者
Phisitkul, S. [2 ]
Hacker, C. [2 ]
Simoni, J. [3 ]
Tran, R. M. [4 ]
Wesson, D. E. [1 ,5 ]
机构
[1] Texas A&M Univ, Hlth Sci Ctr, Dept Internal Med, Temple, TX 76508 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA
[3] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, Lubbock, TX 79430 USA
[4] Texas Tech Univ, Hlth Sci Ctr, Dept Pathol, Lubbock, TX 79430 USA
[5] Scott & White Mem Hosp & Clin, Temple, TX USA
关键词
acid; albuminuria; alkali; blood pressure; bosentan; darusentan; nephrectomy;
D O I
10.1038/sj.ki.5002647
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Dietary casein promotes a progressive decline in the glomerular filtration rate (GFR) of remnant kidneys associated with metabolic acidosis and an endothelin-mediated increase in renal acidification. We tested whether diets that affect the acid-base status contributes to the decline of GFR through endothelin receptors in rats with a remnant kidney. Rats on a casein diet had metabolic acidosis at baseline and developed a progressive decline in GFR after renal mass reduction. Dietary sodium bicarbonate but not sodium chloride ameliorated metabolic acidosis and prevented the decrease in GFR but only after the sodium bicarbonate-induced increase in blood pressure was treated. Dietary soy protein did not induce baseline metabolic acidosis and rats with remnant kidney on a soy diet had no decrease in their GFR. By contrast, rats with a remnant kidney on soy protein given dietary acid developed metabolic acidosis and a decreased GFR. This decline in GFR was prevented in either case by endothelin A but not endothelin A/B receptor antagonism. Our study suggests that the casein-induced decline in GFR of the remnant kidney is mediated by metabolic acidosis through endothelin A receptors.
引用
收藏
页码:192 / 199
页数:8
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