Voltage-gated calcium channels and disease

被引：58

作者：

Cain, Stuart M. ^{[1
]}

Snutch, Terrance P. ^{[1
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

来源：

BIOFACTORS | 2011年 / 37卷 / 03期

基金：

加拿大健康研究院;

关键词：

calcium channel; channelopathies; epilepsy; familial hemiplegic migraine; ataxia; FAMILIAL HEMIPLEGIC MIGRAINE; MALIGNANT HYPERTHERMIA MUTATION; LINKED RETINAL DISORDER; EPISODIC ATAXIA TYPE-2; SPIKE-WAVE SEIZURES; CONE-ROD DYSTROPHY; RAT MODEL; ABSENCE EPILEPSY; CA2+ CHANNELS; MICE LACKING;

D O I：

10.1002/biof.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage-gated calcium channels are a family of integral membrane calcium-selective proteins found in all excitable and many nonexcitable cells. Calcium influx affects membrane electrical properties by depolarizing cells and generally increasing excitability. Calcium entry further regulates multiple intracellular signaling pathways as well as the biochemical factors that mediate physiological functions such as neurotransmitter release and muscle contraction. Small changes in the biophysical properties or expression of calcium channels can result in pathophysiological changes leading to serious chronic disorders. In humans, mutations in calcium channel genes have been linked to a number of serious neurological, retinal, cardiac, and muscular disorders. (C) 2011 International Union of Biochemistry and Molecular Biology, Inc.

引用

页码：197 / 205

页数：9

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