Memory impairments and oxidative stress in the hippocampus of in-utero cocaine-exposed rats

被引：32

作者：

Bashkatova, V

Meunier, J

Maurice, T ^{[1
]}

Vanin, A

机构：

[1] Russian Acad Med Sci, Inst Pharmacol, Dept Neurochem Pharmacol, 8 Baltiyskaya St, Moscow 125315, Russia

[2] Univ Montpellier 2, CNRS, FRE 2693, F-34095 Montpellier, France

[3] Russian Acad Sci, Semenov Inst Chem Phys, Dept Phys Chem & Biopolimeres, Moscow, Russia

来源：

NEUROREPORT | 2005年 / 16卷 / 11期

关键词：

electron paramagnetic resonance; in-utero cocaine exposure; lipid peroxidation; nitric oxide; rat hippocampus; water-maze learning;

D O I：

10.1097/00001756-200508010-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether significant oxidative stress is induced in the brain of juvenile rats exposed in utero to cocaine, and contributes to their mnesic difficulties. We measured nitric oxide generation, using electron paramagnetic resonance, and the thiobarbituric acid reactive species as specific indexes of lipid peroxidation. Both nitric oxide and lipid peroxidation were elevated in the hippocampus of in-utero cocaine-exposed rats as compared with control animals. In-utero cocaine-exposed rats developed significant learning impairments in the water-maze, shown by probe test retrieval deficits. In parallel, behavioural sessions resulted in increases of thiobarbituric acid reactive species levels only in control animals. Therefore, in-utero cocaine exposure resulted in a significant oxidative stress in basal conditions, which may be related to impaired learning ability.

引用

页码：1217 / 1221

页数：5