Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives

被引：37
作者：
Kolokythas, G
Kostakis, IK
Pouli, N
Marakos, P [1 ]
Kletsas, D
Pratsinis, H
机构：
[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece
[2] NCSR Demokritos, Lab Cell Proliferat & Ageing, Inst Biol, Athens 15310, Greece
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 21期
关键词：
D O I：
10.1016/S0968-0896(03)00503-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4591 / 4598
页数：8
相关论文
共 18 条
[1]  
ARCAMONE F, 1985, CANCER RES, V45, P5995
[2]  
BARLOGIE B, 1976, CANCER RES, V36, P1975
[3]  
BELL D, 1995, SYNTHESIS-STUTTGART, P707
[4]   Mitoxantrone-induced bradycardia [J].
Benekli, M ;
Kars, A ;
Guler, N .
ANNALS OF INTERNAL MEDICINE, 1997, 126 (05) :409-409
[5]  
Ghirtis K, 2000, HETEROCYCLES, V53, P93
[6]   IMPROVED SYNTHESIS OF ARYL 1,1-DIMETHYLPROPARGYL ETHERS [J].
GODFREY, JD ;
MUELLER, RH ;
SEDERGRAN, TC ;
SOUNDARARAJAN, N ;
COLANDREA, VJ .
TETRAHEDRON LETTERS, 1994, 35 (35) :6405-6408
[7]   The anthrapyrazoles [J].
Gogas, H ;
Mansi, JL .
CANCER TREATMENT REVIEWS, 1995, 21 (06) :541-552
[8]   CORRELATION OF DNA REACTIVITY AND CYTOTOXICITY OF A NEW CLASS OF ANTICANCER AGENTS - AZA-ANTHRACENEDIONES [J].
HAZLEHURST, LA ;
KRAPCHO, AP ;
HACKER, MP .
CANCER LETTERS, 1995, 91 (01) :115-124
[9]   Design, synthesis, and antiproliferative activity of some new pyrazole-fused amino derivatives of the pyranoxanthenone, pyranothioxanthenone, and pyranoacridone ring systems:: A new class of cytotoxic agents [J].
Kostakis, IK ;
Magiatis, P ;
Pouli, N ;
Marakos, P ;
Skaltsounis, AL ;
Pratsinis, H ;
Léonce, S ;
Pierré, A .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) :2599-2609
[10]  
Krapcho A. Paul, 1997, Drugs of the Future, V22, P641
12