Selection of phages and conditions for the safe phage therapy against Pseudomonas aeruginosa infections

被引：14

作者：

Krylov, Victor ^{[1
]}

Shaburova, Olga ^{[1
]}

Pleteneva, Elena ^{[1
]}

Krylov, Sergey ^{[1
]}

Kaplan, Alla ^{[1
]}

Burkaltseva, Maria ^{[1
]}

Polygach, Olga ^{[1
]}

Chesnokova, Elena ^{[1
]}

机构：

[1] RAMS, II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia

来源：

VIROLOGICA SINICA | 2015年 / 30卷 / 01期

关键词：

BACTERIOPHAGE-PHI-KZ; COMPLETE GENOME SEQUENCE; ESCHERICHIA-COLI; TEMPERATE BACTERIOPHAGE; MU; LAMBDA; INTEGRATION; ENDOLYSINS; RESEMBLES; PROPHAGES;

D O I：

10.1007/s12250-014-3546-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of multidrug-resistant bacterial pathogens forced us to consider the phage therapy as one of the possible alternative approaches to treatment. The purpose of this paper is to consider the conditions for the safe, long-term use of phage therapy against various infections caused by Pseudomonas aeruginosa. We describe the selection of the most suitable phages, their most effective combinations and some approaches for the rapid recognition of phages unsuitable for use in therapy. The benefits and disadvantages of the various different approaches to the preparation of phage mixtures are considered, together with the specific conditions that are required for the safe application of phage therapy in general hospitals and the possibilities for the development of personalized phage therapy.

引用

页码：33 / 44

页数：12

共 68 条

[1]

Abedon Stephen T, 2011, Bacteriophage, V1, P66

[2] Bacteriophages φMR299-2 and φNH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells [J].

Alemayehu, Debebe ;

Casey, Pat G. ;

McAuliffe, Olivia ;

Guinane, Caitriona M. ;

Martin, James G. ;

Shanahan, Fergus ;

Coffey, Aidan ;

Ross, R. Paul ;

Hill, Colin .

MBIO, 2012, 3 (02)

[3] Recombineering A powerful tool for modification of bacteriophage genomes [J].

不详 .

BIOENGINEERED, 2012, 3 (03) :137-137

[4]

[Anonymous], 1989, Cold Spring Harbor

[5] Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa [J].

Briers, Yves ;

Walmagh, Maarten ;

Grymonprez, Barbara ;

Biebl, Manfred ;

Pirnay, Jean-Paul ;

Defraine, Valerie ;

Michiels, Jan ;

Cenens, William ;

Aertsen, Abram ;

Miller, Stefan ;

Lavigne, Rob .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) :3774-3784

[6]

Burkal'tseva M V, 2006, Genetika, V42, P33

[7] STUDIES ON BACTERIOPHAGE-2 RECEPTORS OF PSEUDOMONAS-AERUGINOSA [J].

CASTILLO, FJ ;

BARTELL, PF .

JOURNAL OF VIROLOGY, 1974, 14 (04) :904-909

[8] LOCALIZATION AND FUNCTIONAL ROLE OF PSEUDOMONAS BACTERIOPHAGE 2 DEPOLYMERASE [J].

CASTILLO, FJ ;

BARTELL, PF .

JOURNAL OF VIROLOGY, 1976, 18 (02) :701-708

[9] The intron-containing genome of the lytic Pseudomonas phage LUZ24 resembles the temperate phage PaP3 [J].

Ceyssens, Pieter-Jan ;

Hertveldt, Kirsten ;

Ackermann, Hans-W. ;

Noben, Jean-Paul ;

Demeke, Mekonnen ;

Volckaert, Guido ;

Lavigne, Rob .

VIROLOGY, 2008, 377 (02) :233-238

[10] Development of Giant Bacteriophage φKZ Is Independent of the Host Transcription Apparatus [J].

Ceyssens, Pieter-Jan ;

Minakhin, Leonid ;

Van den Bossche, An ;

Yakunina, Maria ;

Klimuk, Evgeny ;

Blasdel, Bob ;

De Smet, Jeroen ;

Noben, Jean-Paul ;

Blaesi, Udo ;

Severinov, Konstantin ;

Lavigne, Rob .

JOURNAL OF VIROLOGY, 2014, 88 (18) :10501-10510

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