Investigation of the Anxiolytic Effects of Naringenin, a Component of Mentha Aquatica, in the Male Sprague-Dawley Rat

被引：24

作者：

Anderson, Wesley ^{[1
]}

Barrows, Mark ^{[1
]}

Lopez, Fernando ^{[1
]}

Rogers, Sara ^{[1
]}

Ortiz-Coffie, Adriana ^{[1
]}

Norman, David ^{[1
]}

Hodges, Jonathan ^{[1
]}

McDonald, Keith ^{[1
]}

Barnes, Devon ^{[1
]}

McCall, Suzanne ^{[1
]}

Johnson, Arthur Don ^{[1
]}

Ceremuga, Thomas E. ^{[1
]}

机构：

[1] USA, Grad Program Anesthesia Nursing, Washington, DC USA

来源：

HOLISTIC NURSING PRACTICE | 2012年 / 26卷 / 01期

关键词：

anxiolysis; elevated plus maze; mentha aquatica; mint; naringenin; Sprague-Dawley rat; MEDICINE; PLANTS;

D O I：

10.1097/HNP.0b013e31823c003a

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the gamma-aminobutyric acid (GABA(A)) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats per group: control, naringenin, midazolam, midazolam with naringenin, and flumazenil with naringenin. The elevated plus maze measured the behavioral components of anxiety and motor movements. Our data suggest that naringenin does not produce anxiolysis by modulation of the GABA(A) receptor; however, the findings indicate that naringenin decreases motor movements (P < .05).

引用

页码：52 / 57

页数：6

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