Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase

被引：11
作者：
Jang, DS
Park, EJ
Kang, YH
Vigo, JS
Graham, JG
Cabieses, F
Fong, HHS
Pezzuto, JM
Kinghorn, AD
机构：
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[3] INMETRA, Minesterio Salud, Lima, Peru
[4] Purdue Univ, W Lafayette, IN 47907 USA
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 02期
关键词：
Couepia ulei; Chrysobalanoideae; Rosaceae; phenolic compounds; quinone reductase induction; cancer chemoprevention;
D O I：
10.1007/BF02980101
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product, erythro2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, (+/-)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds 1 and 2 exhibited QR inducing activity, with observed CID (concentration required to double induction) values of 16.7 and 16.4 muM, respectively.
引用
收藏
页码：169 / 172
页数：4
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