Autoproteolytic Fragments Are Intermediates in the Oligomerization/Aggregation of the Parkinson's Disease Protein Alpha-Synuclein as Revealed by Ion Mobility Mass Spectrometry

被引：36

作者：

Vlad, Camelia ^{[1
]}

Lindner, Kathrin ^{[1
]}

Karreman, Christiaan ^{[2
]}

Schildknecht, Stefan ^{[2
]}

Leist, Marcel ^{[2
]}

Tomczyk, Nick ^{[3
]}

Rontree, John ^{[3
]}

Langridge, James ^{[3
]}

Danzer, Karin ^{[4
]}

Ciossek, Thomas ^{[4
]}

Petre, Alina ^{[1
,5
]}

Gross, Michael L. ^{[5
]}

Hengerer, Bastian ^{[4
]}

Przybylski, Michael ^{[1
]}

机构：

[1] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

[2] Univ Konstanz, Dept Biol, D-78457 Constance, Germany

[3] Waters Ltd, Manchester M22 5UP, Lancs, England

[4] Bohringer Ingelheim Pharma GmBH & Co KG, ZNS Res, D-88397 Biberach, Germany

[5] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

CHEMBIOCHEM | 2011年 / 12卷 / 18期

关键词：

aggregation; alpha-synuclein; autoproteolytic fragmentation; mass spectrometry; oligomerization; FIBRIL FORMATION; PEPTIDE; IDENTIFICATION; AFFINITY; BINDING; OLIGOMERS; MUTATION; QUANTIFICATION; AGGREGATION; MECHANISM;

D O I：

10.1002/cbic.201100569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2740 / 2744

页数：5

共 62 条

[1]

[Anonymous], 2007, ANGEW CHEM INT ED, V46, P8001

[2]

[Anonymous], 1996, ANGEW CHEM INT ED EN, V35, P806

[3] Copper- and iron-induced differential fibril formation in α-synuclein:: TEM study [J].

Bharathi ;

Indi, S. S. ;

Rao, K. S. J. .

NEUROSCIENCE LETTERS, 2007, 424 (02) :78-82

[4]

Bleiholder C, 2011, NAT CHEM, V3, P172, DOI [10.1038/nchem.945, 10.1038/NCHEM.945]

[5] Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases [J].

Bucciantini, M ;

Giannoni, E ;

Chiti, F ;

Baroni, F ;

Formigli, L ;

Zurdo, JS ;

Taddei, N ;

Ramponi, G ;

Dobson, CM ;

Stefani, M .

NATURE, 2002, 416 (6880) :507-511

[6] Role of Synucleins in Alzheimer's Disease [J].

Crews, Leslie ;

Tsigelny, Igor ;

Hashimoto, Makoto ;

Masliah, Eliezer .

NEUROTOXICITY RESEARCH, 2009, 16 (03) :306-317

[7] Different species of α-synuclein oligomers induce calcium influx and seeding [J].

Danzer, Karin M. ;

Haasen, Dorothea ;

Karow, Anne R. ;

Moussaud, Simon ;

Habeck, Matthias ;

Giese, Armin ;

Kretzschmar, Hans ;

Hengerer, Bastian ;

Kostka, Marcus .

JOURNAL OF NEUROSCIENCE, 2007, 27 (34) :9220-9232

[8] Molecular pathways of neurodegeneration in Parkinson's disease [J].

Dawson, TM ;

Dawson, VL .

SCIENCE, 2003, 302 (5646) :819-822

[9] On-Line Bioaffinity-Electrospray Mass Spectrometry for Simultaneous Detection, Identification, and Quantification of Protein-Ligand Interactions [J].

Dragusanu, Mihaela ;

Petre, Brindusa-Alina ;

Slamnoiu, Stefan ;

Vlad, Camelia ;

Tu, Tingting ;

Przybylski, Michael .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2010, 21 (10) :1643-1648

[10] Spin-Label EPR on α-Synuclein Reveals Differences in the Membrane Binding Affinity of the Two Antiparallel Helices [J].

Drescher, Malte ;

Godschalk, Frans ;

Veldhuis, Gertjan ;

van Rooijen, Bart D. ;

Subramaniam, Vinod ;

Huber, Martina .

CHEMBIOCHEM, 2008, 9 (15) :2411-2416

← 1 2 3 4 5 6 7 →