The relationship of aging to endotoxin shock and to production of TNF-alpha

被引：24

作者：

Chang, HN

Wang, SR

Chiang, SC

Teng, WJ

Chen, ML

Tsai, JJ

Huang, DF

Lin, HY

Tsai, YY

机构：

[1] VET GEN HOSP,DEPT MED,SECT ALLERGY IMMUNOL & RHEUMATOL,TAIPEI 112,TAIWAN

[2] VET GEN HOSP,INFORMAT SERV CTR,TAIPEI 112,TAIWAN

[3] NATL YANG MING UNIV,SCH MED,TAIPEI,TAIWAN

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1996年 / 51卷 / 05期

关键词：

D O I：

10.1093/gerona/51A.5.M220

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background. Aged people are considered prone to gram-negative bacteremia and septic shock. This relationship was tested in murine endotoxin shock. Methods. Balb/c mice of various ages (1.4-13.4 months) were intraperitoneally injected with lipopolysaccharide (LPS), and rates of survival were observed. The production of TNF-alpha in vivo induced by LPS was measured. Results. The survival rates were the smallest in the oldest and youngest groups. Production of TNF-alpha attained a maximum at 2 h after LPS injection and was smaller in the oldest group; it had a reciprocal relationship to survival rates in each group except the youngest group. Conclusion. Old and young mice had smaller rates of survival and greater production of TNF-alpha following endotoxin shock induced by LPS.

引用

页码：M220 / M222

页数：3

共 24 条

[1] GRAM-NEGATIVE SEPTICEMIA - A GROWING THREAT [J].