In vitro activity of essential oils against Pseudomonas aeruginosa isolated from infected hip implants

被引：30

作者：

Amorese, Veronica ^{[1
]}

Donadu, Matthew ^{[2
]}

Usai, Donatella ^{[2
]}

Sannat, Angelino ^{[1
]}

Miliat, Fabio ^{[1
]}

Pisanu, Francesco ^{[1
]}

Molicotti, Paola ^{[2
]}

Zanetti, Stefania ^{[2
]}

Doria, Carlo ^{[1
]}

机构：

[1] Univ Sassari, Orthoped Clin, Dept Surg Microsurg & Med Sci, Sassari, Italy

[2] Univ Sassari, Dept Biomed Sci, Viale San Pietro 43B, I-07100 Sassari, Italy

来源：

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES | 2018年 / 12卷 / 11期

关键词：

Antimicrobials; biopharmaceuticals; hip implants; infection; Pseudomonas spp; PERIPROSTHETIC JOINT INFECTION; ARTHROPLASTY;

D O I：

10.3855/jidc.10988

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Essential oils have been used since ancient times and are known for their anti-inflammmatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris-red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the "in vitro" cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells. Results: Thymus vulgaris-red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.

引用

页码：996 / 1001

页数：6

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