Progress over the first decade of CASP experiments

被引：141
作者：
Kryshtafovych, A
Venclovas, C
Fidelis, K
Moult, J
机构：
[1] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA
[2] Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA USA
[3] Inst Biotechnol, Vilnius, Lithuania
来源：
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2005年 / 61卷
关键词：
protein structure prediction; community wide experiment; CASP;
D O I：
10.1002/prot.20740
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CASP has now completed a decade of monitoring the state of the art in protein structure prediction. The quality of structure models produced in the latest experiment, CASP6, has been compared with that in earlier CASPs. Significant although modest progress has again been made in the fold recognition regime, and cumulatively, progress in this area is impressive. Models of previously unknown folds again appear to have modestly improved, and several mixed alpha/beta structures have been modeled in a topologically correct manner. Progress remains hard to detect in high sequence identity comparative modeling, but server performance in this area has moved forward.
引用
收藏
页码：225 / 236
页数：12
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