Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release

被引：10

作者：

Putra, Masteria Yunovilsa ^{[1
,2
]}

Ianaro, Angela ^{[3
]}

Panza, Elisabetta ^{[3
]}

Bavestrello, Giorgio ^{[4
]}

Cerrano, Carlo ^{[2
]}

Fattorusso, Ernesto ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[3] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[4] Univ Genoa, Dipartimento Studio Terr & Sue Risorse, I-16132 Genoa, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期

关键词：

Sinularia; Indonesia; Glycolipid; Anti-inflammatory; iNOS inhibition; SPONGE APLYSINELLA-RHAX; NITRIC-OXIDE; CEREBROSIDES;

D O I：

10.1016/j.bmcl.2012.02.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded a known glucosylcerebroside of the sarcoehrenoside-type and sinularioside (2), a new naturally triacetylated glycolipid containing two alpha-D-arabinopyranosyl residues and a myristyl alcohol unit. Their complete stereostructures were solved by interpretation of MS and NMR data along with CD analysis of degradation products. Sinularioside proved to moderately inhibit LPS-induced NO release, providing interesting clues into the poorly understood structure-activity relationships for anti-inflammatory glycolipids. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2723 / 2725

页数：3

共 45 条

[41] Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography
Li, Song-Wei
Cuadrado, Cristina
Liu, Jiao
Li, Heng
Tang, Wei
Daranas, Antonio Hernandez
Guo, Yue-Wei
JOURNAL OF CHROMATOGRAPHY A, 2024, 1736
[42] Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies
Abdelhafez, Omnia Hesham
Ali, Taha Farouk Shehata
Fahim, John Refaat
Desoukey, Samar Yehia
Ahmed, Safwat
Behery, Fathy A.
Kamel, Mohamed Salah
Gulder, Tobias A. M.
Abdelmohsen, Usama Ramadan
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 5345 - 5360
[43] Terpioside B, a difucosyl GSL from the marine sponge Terpios sp is a potent inhibitor of NO release
Costantino, Valeria
Fattorusso, Ernesto
Mangoni, Alfonso
Teta, Roberta
Panza, Elisabetta
Ianaro, Angela
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (14) : 5310 - 5315
[44] Total synthesis of splenocin B, a potent inhibitor of the pro-inflammatory cytokine from marine-derived Streptomyces sp.
Yoshida, Ken-ichi
Ijiri, Minako
Iio, Hideo
Usuki, Yoshinosuke
TETRAHEDRON, 2015, 71 (52) : 9626 - 9629
[45] (1R,7R,8R,11R,12R)-7,8:11,12-Bisepoxycembrene A: A novel cembranoid from octocoral Sinularia sp.
Tseng, Hsuan-Jung
Chien, Su-Ying
Wen, Zhi-Hong
Kuo, Jimmy
Fang, Lee-Shing
Wu, Yang-Chang
Wu, Tung-Ying
Sung, Ping-Jyun
TETRAHEDRON LETTERS, 2022, 90

← 1 2 3 4 5 →