Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release

被引：10
|
作者：
Putra, Masteria Yunovilsa [1 ,2 ]
Ianaro, Angela [3 ]
Panza, Elisabetta [3 ]
Bavestrello, Giorgio [4 ]
Cerrano, Carlo [2 ]
Fattorusso, Ernesto [1 ]
Taglialatela-Scafati, Orazio [1 ]
机构：
[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[2] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy
[3] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy
[4] Univ Genoa, Dipartimento Studio Terr & Sue Risorse, I-16132 Genoa, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期
关键词：
Sinularia; Indonesia; Glycolipid; Anti-inflammatory; iNOS inhibition; SPONGE APLYSINELLA-RHAX; NITRIC-OXIDE; CEREBROSIDES;
D O I：
10.1016/j.bmcl.2012.02.102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded a known glucosylcerebroside of the sarcoehrenoside-type and sinularioside (2), a new naturally triacetylated glycolipid containing two alpha-D-arabinopyranosyl residues and a myristyl alcohol unit. Their complete stereostructures were solved by interpretation of MS and NMR data along with CD analysis of degradation products. Sinularioside proved to moderately inhibit LPS-induced NO release, providing interesting clues into the poorly understood structure-activity relationships for anti-inflammatory glycolipids. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2723 / 2725
页数：3
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