Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release

被引：10

作者：

Putra, Masteria Yunovilsa ^{[1
,2
]}

Ianaro, Angela ^{[3
]}

Panza, Elisabetta ^{[3
]}

Bavestrello, Giorgio ^{[4
]}

Cerrano, Carlo ^{[2
]}

Fattorusso, Ernesto ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[3] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[4] Univ Genoa, Dipartimento Studio Terr & Sue Risorse, I-16132 Genoa, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期

关键词：

Sinularia; Indonesia; Glycolipid; Anti-inflammatory; iNOS inhibition; SPONGE APLYSINELLA-RHAX; NITRIC-OXIDE; CEREBROSIDES;

D O I：

10.1016/j.bmcl.2012.02.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded a known glucosylcerebroside of the sarcoehrenoside-type and sinularioside (2), a new naturally triacetylated glycolipid containing two alpha-D-arabinopyranosyl residues and a myristyl alcohol unit. Their complete stereostructures were solved by interpretation of MS and NMR data along with CD analysis of degradation products. Sinularioside proved to moderately inhibit LPS-induced NO release, providing interesting clues into the poorly understood structure-activity relationships for anti-inflammatory glycolipids. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2723 / 2725

页数：3

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