Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats

被引：65

作者：

Song, Nan ^{[1
]}

Zhao, Zhihu ^{[2
,3
]}

Ma, Xinlong ^{[2
]}

Sun, Xiaolei ^{[2
]}

Ma, Jianxiong ^{[2
]}

Li, Fengbo ^{[2
]}

Sun, Lei ^{[2
]}

Lv, Jianwei ^{[2
]}

机构：

[1] Tianjin Huanhu Hosp, 6 Jizao Rd, Tianjin 300350, Peoples R China

[2] Tianjin Inst Orthoped Tradit Chinese & Western Me, 122 Munan Rd, Tianjin 300050, Peoples R China

[3] Tianjin Med Univ, Grad Sch, Tianjin, Peoples R China

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2017年 / 261卷

基金：

中国国家自然科学基金;

关键词：

Angiogenesis; Naringin; VEGF; VEGFR-2; ENDOTHELIAL GROWTH-FACTOR; BONE-MINERAL DENSITY; OVARIECTOMIZED MICE; MARROW PERFUSION; VEGF; MODULATION; EXPRESSION; IMPROVES; REPAIR; CELLS;

D O I：

10.1016/j.cbi.2016.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：11 / 17

页数：7

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