Effect of Disordered Structure of Boron-Containing Calcium Phosphates on their In Vitro Biodegradability

被引：28

作者：

Barheine, Sabrina ^{[2
]}

Hayakawa, Satoshi ^{[1
,3
]}

Jaeger, Christian ^{[2
]}

Shirosaki, Yuki ^{[1
]}

Osaka, Akiyoshi ^{[1
,3
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Biomat Lab, Okayama 7008530, Japan

[2] BAM Fed Inst Mat Res & Testing, Div I3, D-12489 Berlin, Germany

[3] Okayama Univ, Biomed Engn Res Ctr, Okayama 7008530, Japan

来源：

JOURNAL OF THE AMERICAN CERAMIC SOCIETY | 2011年 / 94卷 / 08期

基金：

日本学术振兴会;

关键词：

BETA-TRICALCIUM PHOSPHATE; SELECTIVE PROTEIN ADSORPTION; CONTROLLED-RELEASE; HYDROXYAPATITE; SURFACE; ZINC; BORATE;

D O I：

10.1111/j.1551-2916.2011.04400.x

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This study proposes a new guideline for designing biodegradable apatite ceramics. Boron-containing hydroxyapatite (BHAp) particles were prepared by a high-temperature solid-state reaction processing method and were characterized in terms of their chemical composition, apatite lattice defects and in vitro biodegradability. Solid-state nuclear magnetic resonance analysis showed that boron-incorporation into hydroxyapatite (HAp) derived by thermo-chemical reactions between borate and calcium phosphate phases led to disordered phases (BCaP) of a CaO-P2O5-B2O3-OH system covering the crystalline HAp core. X-ray diffraction analysis indicated that the BCaP phase must consist mainly of a crystalline oxyboroapatite (OBAp) phase. An in vitro biodegradability test showed that BHAp degraded quicker than HAp or beta-tricalcium phosphate. The biodegradability of BHAp particles can be controlled by boron incorporation into a HAp lattice leading to the formation of a disordered OBAp phase.

引用

页码：2656 / 2662

页数：7

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