STUDIES OF 5-HTTLPR POLYMORPHISM OF SEROTONIN TRANSPORTER GENE (LITERATURE REVIEW)

Serotonin transporter gene 5-HTTLPR polymorphism is one of the most studied markers of the serotonergic system. Scientific interest in its study is due to the fact that many studies have shown the connection of the short allele (S) with the development of a number of mental illnesses. A series of studies have also shown that different alleles of 5-HTTLPR are associated with different patterns of brain bioelectric activity at rest or when performing test tasks. However, despite a large number of studies of this marker, their results often contradict each other. Possible reasons for the inconsistency of the results may be as follows: ignoring the complex structure of the SLC6A4 gene, heterogeneity of the samples, the difference in the methods used. The aim of this work is to conduct a comprehensive analysis of psychological, behavioral, genetic and neurophysiological data based on a literature review, which will allow us to generalize the effects associated with 5-HTTLPR polymorphism, as well as at least partially explain the ambiguity of the results obtained by different authors.