Interfacial Cocrystallization Using Oily Phase via Liquid-Liquid Phase Separation

被引：3

作者：

Al-Hanafi, M. Asim Sajid ^{[1
]}

Alsirawan, Mhd Bashir ^{[1
]}

Seaton, Colin C. ^{[2
]}

Swift, Thomas ^{[2
]}

Pagire, Sudhir ^{[1
]}

Vangala, Venu R. ^{[1
]}

Kelly, Adrian L. ^{[3
]}

Paradkar, Anant ^{[1
]}

机构：

[1] Univ Bradford, Ctr Pharmaceut Engn Sci, Sch Pharm & Med Sci, Bradford BD7 1DP,, England

[2] Univ Bradford, Sch Chem & Biosci, Bradford BD7 1DP, England

[3] Univ Bradford, Fac Engn & Informat, Ctr Pharmaceut Engn Sci, Bradford BD7 1DP, England

来源：

CRYSTAL GROWTH & DESIGN | 2022年 / 22卷 / 10期

关键词：

CRYSTALLIZATION; NUCLEATION; MORPHOLOGY; VANILLIN;

D O I：

10.1021/acs.cgd.2c00263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cocrystals consist of two molecules bonded together in a single crystal lattice giving rise to wide applications including improving solubility of poorly soluble pharmaceuticals. Cocrystallization reaction occurs in the oily phase of liquid-liquid phase separation (LLPS) after it is mixed with coformers. Indomethacin- saccharin cocrystal formation was monitored in situ, and the kinetics of crystallization were determined. The crystallization rates show that the process can be proposed to prevent unwanted oily phase formation during LLPS.

引用

页码：5845 / 5851

页数：7

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