Experimental murine model for autoimmune enterocolitis using Klebsiella pneumoniae O3 lipopolysaccharide as a potent immunological adjuvant

被引:10
作者
Paeng, N
Morikawa, A
Kato, Y
Sugiyama, T
Koide, N
Yoshida, T
Yokochi, T [1 ]
机构
[1] Aichi Med Univ, Dept Immunol & Microbiol, Nagakute, Aichi 4801195, Japan
[2] Aichi Med Univ, Res Ctr Infect Dis, Nagakute, Aichi 4801195, Japan
关键词
enterocolitis; lipopolysaccharide; LPS; Klebsiella pneumoniae;
D O I
10.1111/j.1348-0421.1999.tb02371.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An experimental model for autoimmune enterocolitis was produced in mice by repeated immunization of homologous colon extract together with Klebsiella O3 lipopolysaccharide (KO3 LPS) as an immunological adjuvant. Histological changes in the intestinal lesions were characterized by infiltration with polymorphonuclear leukocytes in the lamina propria, muscularis mucosae and submucosa of repeatedly immunized mice. No such intestinal lesions were produced in mice receiving injections of colon extract alone or KO3 LPS alone. Development of the autoantibody and delayed-type hypersensitivity against colon extract were found in mice immunized with the mixture of colon extract and KO3 LPS, Distinct positive staining was detected specifically on the columnar epithelium of villi, Sera from hyperimmunized mice defined organ-specific antigens present in the intestine. Therefore, it was suggested that the intestinal lesions might be caused by an autoimmune mechanism.
引用
收藏
页码:45 / 52
页数:8
相关论文
共 40 条
[1]  
ASHERSON GL, 1966, IMMUNOLOGY, V10, P161
[2]   IMMUNOLOGIC COLITIS IN DOGS [J].
BICKS, RO ;
WALKER, RH .
AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1962, 7 (06) :574-&
[3]   AUTOANTIBODIES IN HUMAN ULCERATIVE COLITIS [J].
BROBERGER, O ;
PERLMANN, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 1959, 110 (05) :657-674
[4]   IMMUNOLOGICAL STUDIES IN ULCERATIVE-COLITIS .8. ANTIBODIES TO COLON ANTIGEN IN PATIENTS WITH ULCERATIVE-COLITIS, CROHNS-DISEASE, AND OTHER DISEASES [J].
CARLSSON, HE ;
LAGERCRANTZ, R ;
PERLMANN, P .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1977, 12 (06) :707-714
[5]  
DAS KM, 1993, J IMMUNOL, V150, P2487
[6]   IMMUNOPATHOLOGICAL AND IMMUNOCHEMICAL ANALYSIS OF AUTOIMMUNE ENTEROCOLITIS IN MICE [J].
DESPRES, N ;
NEMIROVSKY, MS .
DIGESTION, 1991, 49 (02) :106-119
[7]  
DIELEMAN LA, 1997, SCAND J GASTROENTERO, V223, pS99
[8]   ISO-ANTIBODIES TO COLON [J].
FORD, H ;
KIRSNER, JB .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1967, 31 (05) :449-&
[9]   EXPERIMENTAL AUTOIMMUNE ADRENALITIS - A MURINE MODEL FOR ADDISONS-DISEASE [J].
FUJII, Y ;
KATO, N ;
KITO, J ;
ASAI, J ;
YOKOCHI, T .
AUTOIMMUNITY, 1992, 12 (01) :47-52
[10]  
FUJII Y, 1991, MED MICROBIOL IMMUN, V180, P1