Innate Lymphocyte Mechanisms in Skin Diseases

被引：15

作者：

Chen, Yi-Ling ^{[1
]}

Hardman, Clare S. ^{[1
]}

Yadava, Koshika ^{[1
]}

Ogg, Graham ^{[1
,2
]}

机构：

[1] MRC Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DS, England

[2] Oxford Univ Hosp, NIHR Oxford Biomed Res Ctr, Oxford OX3 7LE, England

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 | 2020年 / 38卷

基金：

英国医学研究理事会;

关键词：

lymphocytes; innate; skin; DELTA-T-CELLS; RECEPTOR-GAMMA-DELTA; INTERLEUKIN-36-RECEPTOR ANTAGONIST DEFICIENCY; ALLERGIC CONTACT-DERMATITIS; ENDOTHELIAL PROTEIN-C; HUMAN CD1A DEFICIENCY; NATURAL-KILLER-CELLS; INVARIANT NKT CELLS; ATOPIC-DERMATITIS; LANGERHANS CELLS;

D O I：

10.1146/annurev-immunol-082919-093554

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphocyte populations are emerging as key effectors in tissue homeostasis, microbial defense, and inflammatory skin disease. The cells are evolutionarily ancient and carry conserved principles of function, which can be achieved through shared or unique specific mechanisms. Recent technological and treatment advances have provided insight into heterogeneity within and between individuals and species. Similar pathways can extend through to adaptive lymphocytes, which softens the margins with innate lymphocyte populations and allows investigation of nonredundant pathways of immunity and inflammation that might be amenable to therapeutic intervention. Here, we review advances in understanding of innate lymphocyte biology with a focus on skin disease and the roles of commensal and pathogen responses and tissue homeostasis.

引用

页码：171 / 202

页数：32

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