Chemical Tools for Dissecting the Role of lncRNAs in Epigenetic Regulation

被引：6

作者：

Nainar, Sarah ^{[1
]}

Feng, Chao ^{[1
]}

Spitale, Robert C. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA 92697 USA

来源：

ACS CHEMICAL BIOLOGY | 2016年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

LONG NONCODING RNAS; CHROMATIN-MODIFYING COMPLEXES; EMBRYONIC STEM-CELLS; SECONDARY STRUCTURE; X-CHROMOSOME; DOSAGE COMPENSATION; BINDING PROTEINS; GENE-EXPRESSION; MALE DROSOPHILA; CROSS-LINKING;

D O I：

10.1021/acschembio.6b00366

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proper control and maintenance of gene expression is critical for cellular identity and maintenance. Transcription of RNA from the genome is intimately controlled by post-translational chemical modification of histone tails and DNA. Recent studies have demonstrated that chromatin-remodeling complexes seek out their target genomic loci through the help of noncoding RNA molecules. Within this Review, we will outline how the use of biochemical techniques has shed light on the mechanisms employed by RNA to guide these complexes and therefore control gene expression.

引用

页码：2091 / 2100

页数：10

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