Correlation between Congenital Heart Defects and Maternal Copper and Zinc Concentrations

被引：29

作者：

Hu, Hui ^{[1
,2
]}

Liu, Zhen ^{[1
,3
]}

Li, Jun ^{[4
]}

Li, Shengli ^{[5
]}

Tian, Xiaoxian ^{[6
]}

Lin, Yuan ^{[7
]}

Chen, Xinlin ^{[8
]}

Yang, Jiaxiang ^{[9
]}

Deng, Ying ^{[1
,3
]}

Li, Nana ^{[1
,3
]}

Wang, Yanping ^{[1
]}

Yuan, Ping ^{[2
]}

Li, Xiaohong ^{[1
,3
]}

Zhu, Jun ^{[1
]}

机构：

[1] Sichuan Univ, West China Univ Hosp 2, Natl Ctr Birth Defect Monitoring, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Univ Hosp 2, Lab Mol Epidemiol Birth Defects, Chengdu 610041, Sichuan, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Ultrasound, Xian 710032, Shanxi, Peoples R China

[5] Shenzhen Matern & Child Healthcare Hosp, Dept Ultrasound, Shenzhen, Guangdong, Peoples R China

[6] Maternal & Child Healthcare Hosp Guangxi Zhuang A, Dept Ultrasound, Nanning, Guangxi, Peoples R China

[7] Fujian Prov Maternal & Child Healthcare Hosp, Dept Obstet & Gynecol, Fuzhou, Fujian, Peoples R China

[8] Hubei Prov Maternal & Child Healthcare Hosp, Dept Ultrasound, Wuhan, Hubei, Peoples R China

[9] Sichuan Prov Maternal & Child Healthcare Hosp, Dept Ultrasound, Chengdu, Sichuan, Peoples R China

来源：

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY | 2014年 / 100卷 / 12期

关键词：

Pregnancy; Congenital Heart Defect; zinc and copper concentrations; hair analysis; INDUCED OXIDATIVE STRESS; TRANSCRIPTION FACTOR; DEFICIENCY; EMBRYOS; TRACT;

D O I：

10.1002/bdra.23284

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundThe aim of this study was to investigate the correlation between maternal concentrations of copper and zinc and the risk of having an infant with a congenital heart defect (CHD). MethodsA multi-center hospital-based case-control study was conducted in China. A total of 212 cases and 212 controls were recruited from pregnant women who received prenatal examinations in four tertiary hospitals accredited to perform prenatal diagnosis in the cities of Shenzhen, Zhenzhou, Fuzhou and Wuhan between February 2010 and November 2011. Correlation between CHDs and maternal copper and zinc concentrations was estimated by a 1:1 conditional logistic regression. Also the interaction between copper and zinc was analyzed. ResultsCompared with the controls, mothers with hair copper concentrations of 17.77 g/g or more were more likely to have a child with a CHD than those with a lower concentration. The adjusted odds ratio was 5.70 (95% confidence interval, 2.58-12.61) for CHDs and 6.32 (95% confidence interval, 2.11-18.92) for conotruncal defects. Zinc concentrations were not significantly different in the case and control groups. The results suggest that mothers whose zinc content was 104.60 g/g or less did not have a significantly higher risk of having a child with a CHD. No interaction between maternal copper and zinc concentrations was observed in the multiplicative or additive model. ConclusionWomen with excessive copper concentrations have a significantly increased risk of having offspring with a CHD. A low maternal zinc status might have a correlation with CHDs, and an interaction between copper and zinc might exists, but an epidemiological study with a larger sample size is needed to confirm this finding. Birth Defects Research (Part A), 2014. (c) 2014 Wiley Periodicals, Inc. Birth Defects Research (Part A) 100:965-972, 2014. (c) 2014 Wiley Periodicals, Inc.

引用

页码：965 / 972

页数：8

共 37 条

[1] Calculating measures of biological interaction [J].