Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands

被引:82
作者
Kremen, WS
Faraone, SV
Seidman, LJ
Pepple, JR
Tsuang, MT
机构
[1] Univ Calif Davis, Sch Med, Dept Psychiat, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Napa State Hosp, Napa Psychiat Res Ctr, Napa, CA 94558 USA
[3] Harvard Univ, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA
[4] Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
[5] Harvard Univ, Brockton W Roxbury Vet Affairs Med Ctr, Dept Psychiat, Brockton, MA 02401 USA
[6] Massachusetts Mental Hlth Ctr, Neuropsychol Lab, Boston, MA 02115 USA
[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
关键词
neuropsychology; risk indicators; genetics; memory; attention;
D O I
10.1016/S0165-1781(98)00042-0
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Evidence of subtle neuropsychological deficits in relatives of schizophrenic probands (REL-SZs) suggests that these are risk indicators for schizophrenia, but little is known about whether neuropsychological performance in REL-SZs differs from that in other groups of relatives. We compared neuropsychological function in female REL-SZs (n = 39), relatives of primarily psychotic bipolar disorder probands (REL-BPs; n = 15), and a normal control group (n = 44). After adjustment for expected intellectual ability (based on reading recognition), REL-SZs showed deficits in verbal and visual memory (Wechsler Memory Scale-Revised logical memories, visual reproductions), and auditory attention (dichotic digits) compared with either REL-BPs or control subjects. Memory, but not dichotic listening differences remained significant after adjusting for current IQ; however, average effect sizes after controlling for either reading or IQ were roughly comparable for these three parameters (d = 0.80, 0.71, and 0.69, respectively). REL-BPs and control subjects showed little difference. Although both schizophrenic and bipolar patients often manifest neuropsychological dysfunction, these preliminary findings indicate subtle neuropsychological deficits only in REL-SZs. Such differences suggest different underlying processes; neuropsychological impairment may, in part, reflect an expression of genetic liability to schizophrenia but not bipolar disorder. Replication with lager REL-BP sample and with male relatives is needed to evaluate the generalizability of the results. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:227 / 240
页数:14
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