Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

被引：6

作者：

Huo, Xing-xing ^{[1
,2
]}

Wang, Shu-jie ^{[2
]}

Song, Hang ^{[3
]}

Li, Ming-de ^{[1
]}

Yu, Hua ^{[4
]}

Wang, Meng ^{[2
]}

Gong, Hong-xiao ^{[1
]}

Qiu, Xiao-ting ^{[1
]}

Zhu, Yong-fu ^{[1
]}

Zhang, Jian-ye ^{[5
,6
]}

机构：

[1] Anhui Univ Chinese Med, Affiliated Hosp 1, Sci Res Dept, Expt Ctr Clin Res, Hefei, Peoples R China

[2] Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei, Peoples R China

[3] Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China

[4] Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macau, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou, Peoples R China

[6] Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

RNA modification; N; 6-methyladenosine; 1-methyladenosine; alternative polyadenylation; adenosine-to-inosine editing; head and neck squamous cell carcinoma; immunotherapy; POLY(A) TAIL LENGTH; MESSENGER-RNA; ALTERNATIVE POLYADENYLATION; METHYLATION REGULATORS; RETROSPECTIVE ANALYSIS; M(6)A METHYLATION; TUMOR-SUPPRESSOR; METTL3; PROMOTES; GENE FAMILY; GENOME-WIDE;

D O I：

10.3389/fphar.2021.779779

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood. Modifications on RNA are involved in many pathophysiological processes, such as tumor development and inflammation. Adenosine-related RNA modifications have shown to be linked to cancer and may play a role in cancer occurrence and development. To date, there are at least 170 different chemical RNA modifications that modify coding and non-coding RNAs (ncRNAs). These modifications affect RNA stability and transcription efficiency. In this review, we focus on the current understanding of the four major RNA adenosine modifications (N-6-Methyladenosine, N-1-Methyladenosine, Alternative Polyadenylation Modification and A-to-I RNA editing) and their potential molecular mechanisms related to HNSCC development and progression. We also touch on how these RNA modifications affect treatment of HNSCCs.

引用

页数：17

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