The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis

被引：19
作者：
Carol, Emily E. [1 ]
Spencer, Robert L. [1 ]
Mittal, Vijay A. [2 ]
机构：
[1] Univ Colorado, Dept Psychol & Neurosci, Ctr Neurosci, Boulder, CO 80309 USA
[2] Northwestern Univ, Dept Psychol, Dept Psychiat, Inst Policy Res,Dept Medial Social Sci, Evanston, IL 60208 USA
来源：
PSYCHONEUROENDOCRINOLOGY | 2017年 / 83卷
基金：
美国国家卫生研究院;
关键词：
Cortisol; Cannabis; HPA axis; Prodrome; High-Risk; Schizophrenia; CLINICAL HIGH-RISK; PITUITARY-ADRENAL AXIS; MINOR PHYSICAL ANOMALIES; SUBSTANCE USE DISORDERS; AWAKENING RESPONSE; STRESS-RESPONSE; SEX-DIFFERENCES; INDIVIDUALS; ADOLESCENTS; SCHIZOPHRENIA;
D O I：
10.1016/j.psyneuen.2017.04.017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine panel and self-report. UHR participants where separated into two groups: Current Cannabis Use (UHR-CU) and No Current Cannabis Use (UHR-NC). Healthy Control participants (HC) were free of cannabis use. Consistent with the literature, results indicate UHR individuals showed elevated cortisol levels when compared to HC participants. Further, we also observed that UHR-CU participants exhibited elevated levels when compared to both the non-using UHR and HC groups. Findings suggest that cannabis use may interact with underlying biological vulnerability associated with the hypothalamic-pituitary-adrenal (HPA) axis system.
引用
收藏
页码：58 / 64
页数：7
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